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System and method for ocular iontophoresis with buffering

A technology of iontophoresis and buffer system, which is applied in electrotherapy, ophthalmology treatment, medical treatment, etc.

Inactive Publication Date: 2012-02-01
EYEGATE PHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, ophthalmic iontophoresis presents several unique challenges

Method used

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  • System and method for ocular iontophoresis with buffering
  • System and method for ocular iontophoresis with buffering
  • System and method for ocular iontophoresis with buffering

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Embodiment Construction

[0039] As described herein, various embodiments of compositions, devices, methods of use, and methods of manufacture for transocular delivery of a therapeutic substance via iontophoresis across the surface of the eyeball are intended to achieve buffering of the therapeutic substance during iontophoretic treatment to At least one (eg primary) purpose of a biologically acceptable pH range. Another object of at least some of the various embodiments is to maximize electrical delivery of a therapeutic substance by maintaining the pH to achieve the highest ionization level of the therapeutic substance. Another benefit of maintaining the pH of the therapeutic substance is consistent / predictable dose delivery. It is a further object of at least some of the various embodiments to increase the delivery of therapeutic substance(s) to the eye and maintain therapeutic substance(s) during iontophoresis and storage by reducing the amount of competing ions one or more) stability.

[0040] ...

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Abstract

Compositions, devices, methods of manufacture, and methods of delivery of a therapeutic substance across a surface of an eyeball via iontophoresis including a therapeutic media reservoir and a buffer system within an iontophoretic chamber. When energized, an electrode provides an electromotive force that transfers a dosage of the therapeutic substance from the iontophoretic chamber across the surface of the eyeball. The buffering system includes a buffer media and at least one buffer element, or agent that regulates pH during iontophoretic transfer of the therapeutic substance. The buffer media includes at least one of a foam, a gel (solid or liquid), a membrane, and a plurality of multiparticulates. The buffer media can be included within the iontophoretic chamber, together with the therapeutic media reservoir, in various arrangements including one or more layers and one or more concentric cylinders.

Description

[0001] related application [0002] This application claims the benefit of US Provisional Application 61 / 141,994, filed December 31, 2008, and US Provisional Application 61 / 180,602, filed May 22, 2009, the entire contents of each of which are hereby incorporated by reference. technical field [0003] The technology described herein generally relates to systems and methods for transocular delivery of therapeutic substances across the surface of the eyeball via iontophoresis. In some embodiments, the technology relates to buffer systems and methods for adjusting the pH of a therapeutic substance during iontophoresis. Background technique [0004] Ophthalmic iontophoresis is the use of an electrical source to propel charged and / or active molecules from a reservoir into the intraocular tissues of a mammal, including a human or animal. Positively charged ions are driven into ocular tissue by electrical repulsion at the anode, while negatively charged ions are repelled from the c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/30
CPCA61N1/0444A61N1/325A61N1/0448A61N1/303A61F9/0026
Inventor P.莫斯勒米M.曼佐W.舒伯特W.伊索姆R.皮埃尔
Owner EYEGATE PHARMA INC