Purpose of ginkgolic acid in preparing external preparation for treating venereal disease, gynopathy and perianal disease

A technology of ginkgolic acid and external preparations, applied in the field of biomedicine, can solve the problems of easy recurrence, side effects, and slow effect, and achieve significant therapeutic effect, safe use, no side effects, and excellent curative effect

Inactive Publication Date: 2012-02-15
王青
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of these diseases are treated with antibacterial drugs, antiviral drugs or antifungal drugs, as well as corticosteroid hormones and immunosuppressants. Although these drugs have a temporary effect, they are slow to take effect and easy to relapse after drug withdrawal; side effect
There is no report on the use of ginkgolic acid in the preparation of external preparations for the treatment of venereal diseases, gynecological diseases and perianal diseases

Method used

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  • Purpose of ginkgolic acid in preparing external preparation for treating venereal disease, gynopathy and perianal disease
  • Purpose of ginkgolic acid in preparing external preparation for treating venereal disease, gynopathy and perianal disease
  • Purpose of ginkgolic acid in preparing external preparation for treating venereal disease, gynopathy and perianal disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The extraction process of ginkgolic acid from the ginkgo fruit outer testa is as follows: the ginkgo fruit outer testa is peeled off, dried in the sun, and pulverized with a pulverizer. Accurately weigh a certain amount of crushed ginkgo testa, add 80% ethanol with a material-to-liquid ratio of 1:6 (W / V), stir and extract twice at a water bath temperature of 60°C, and extract for 4 hours each time , (Note: After adding liquid, seal the mouth of the beaker with plastic wrap to prevent the volatilization of ethanol). After the leaching is finished, filter with a suction filter to collect the filtrate. Concentrate the filtrate with a vacuum rotary evaporator at a temperature of 55° C. and a pressure of 0.008-0.009 MPa, and concentrate under reduced pressure. Vacuum-dried at 60°C to obtain ginkgolic acid extract. The properties are: light brown extract, slightly smelly, soluble in alcohol, insoluble in water; weighed, and determined the content of ginkgolic acid (mg / g).

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Embodiment 2

[0027] The extraction process of ginkgo phenolic acid from ginkgo fruit ginkgo is as follows: peel the ginkgo fruit, put it into a tissue grinder, and pulverize it. Accurately weigh a certain amount of pulverized Ginkgo fruit, add 80% ethanol with a solid-liquid ratio of 1:10 (W / V), and stir and extract twice at a water bath temperature of 60° C., each extraction time is 4 hours, (Note : After adding liquid, the mouth of the beaker is sealed with plastic wrap to prevent the volatilization of ethanol). After leaching finishes, centrifuge (5000 rpm, 15 minutes), get supernatant. Concentrate the supernatant with a vacuum rotary evaporator under the conditions of temperature 55°C, pressure 0.008-0.009MPa, concentrate under reduced pressure, and vacuum-dry at 60°C to obtain ginkgolic acid extract, which has the following properties: light brown extract, slightly odorous , Soluble in alcohol, insoluble in water. Weigh and determine the content of ginkgolic acid (mg / g).

[0028] G...

Embodiment 3

[0032] The extraction process of ginkgophenolic acid in ginkgo leaves is as follows: cut the ginkgo leaves into pieces, put them into a pulverizer and pulverize them. Accurately take a certain amount of crushed Ginkgo biloba, add 80% ethanol with a solid-liquid ratio of 1:6 (W / V), and stir and extract 2 times at a water bath temperature of 60° C., each extraction time is 4 hours, ( Note: After adding liquid, seal the mouth of the beaker with plastic wrap to prevent the volatilization of ethanol). After leaching finishes, centrifuge (5000 rpm, 15 minutes), get supernatant. Concentrate the supernatant with a vacuum rotary evaporator under the conditions of temperature 55°C, pressure 0.008-0.009MPa, concentrate under reduced pressure, and vacuum-dry at 60°C to obtain ginkgolic acid extract, which has the following properties: light brown extract, slightly odorous , Soluble in alcohol, insoluble in water. Weigh and determine the content of ginkgolic acid (mg / g).

[0033] Ginkgoli...

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Abstract

The invention relates to purpose of ginkgolic acid in preparing external preparations for treating venereal diseases, gynopathy and perianal diseases. The ginkgolic acid comprises ginkgolic acid, ginkgol, ginkgo dipenol, etc., and can be obtained from extractives of ginkgo leaf, fruit, episperm and rhizome through a chemical separation method. The venereal diseases comprise infectious and inflammatory genital diseases. A medicament, a disinfectant or external preparation containing ginkgolic acid for treating venereal diseases, gynopathy and perianal diseases comprises 0.001-80wt% of ginkgolic acid and a pharmaceutically common used external preparation matrix or a pharmaceutically accepted carrier, wherein the preparation is any pharmaceutical external dosage form. Pharmacological tests show that the preparation of the invention has substantial effects of killing resident pathogens on or surrounding genitals, resisting inflammation, relieving pain and itching. Clinic trials show that the preparation of the invention has outstanding curative effects on a plurality of venereal diseases, gynopathy and perianal diseases and an effective rate of 100%, and is safe for usage without side effect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the use of ginkgolic acid in preparing external preparations for treating venereal diseases, gynecological diseases and perianal diseases. Background technique [0002] Sexually transmitted diseases, gynecological diseases and perianal diseases are one of the most common clinical diseases. With the improvement of people's living standards, there is an increasing trend in various places year by year. Because this type of disease lasts for a long time, it is easy to show effect repeatedly, which brings pain to the patient and seriously affects the physical and mental health of the patient. Such diseases are mostly related to genital and surrounding resident pathogen infections, such as gonorrhea, Trichomonas vaginalis, Candida albicans, chlamydia, herpes virus, Treponema pallidum, pubic lice and other infections, causing a variety of sexually transmitted diseases suc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61P15/00A61P15/02A61P1/00A61P9/14A61P31/00A61P33/02A61P33/14A61K31/60A61K31/05A61K125/00A61K127/00A61K131/00
Inventor 王青雷红
Owner 王青
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