Effervescent agent for exterior syndrome relieving and summer heat dispelling, preparation method thereof and purpose thereof

An effervescent agent and effervescent disintegrating agent technology, which is applied in the directions of medical preparations, pharmaceutical formulations, and drug delivery containing active ingredients, can solve the problems of difficult storage, inconvenience in taking and carrying dosage forms, and achieves easy portability, The effect of stable quality and high bioavailability

Active Publication Date: 2014-03-26
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the problem with these prescriptions is that the dosage forms are not convenient enough to take and carry or not easy to store.
But there is still no application in the medicine for the treatment of above-mentioned Shushi cold

Method used

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  • Effervescent agent for exterior syndrome relieving and summer heat dispelling, preparation method thereof and purpose thereof
  • Effervescent agent for exterior syndrome relieving and summer heat dispelling, preparation method thereof and purpose thereof
  • Effervescent agent for exterior syndrome relieving and summer heat dispelling, preparation method thereof and purpose thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0123] API:

[0124] Cangzhu 80g Chenpi 80g Magnolia officinalis (made from ginger) 80g

[0125] Angelica dahurica 120g Poria cocos 120g Big belly skin 120g

[0126] Raw Pinellia 80g Licorice Extract 10g Patchouli Oil 0.8ml

[0127] Perilla leaf oil 0.4ml

[0128] Preparation Process:

[0129] Take Angelica dahurica, soak in 60% ethanol for more than 4 hours, reflux extraction for 1 hour, dynamic heat reflux extraction for 6 hours, recover ethanol, concentrate to a relative density of 1.10-1.12; take Atractylodes rhizome, add 70% ethanol for 4 hours, reflux extraction for 1 hour , dynamic hot reflux extraction for 6 hours, recovered ethanol, concentrated to a relative density of 1.03-1.05; magnolia bark was crushed into coarse powder, added 4 times the amount of 90% ethanol, soaked for more than 4 hours, cold reflux extraction for 4 hours, dynamic hot reflux extraction for 12 Hours, reclaim ethanol, make alcohol content reach 55%-60%; Get licorice extract and add drinking ...

Embodiment 2

[0132] Cangzhu 80g Chenpi 80g Magnolia officinalis (made from ginger) 80g

[0133] Angelica dahurica 120g Poria cocos 120g Big belly skin 120g

[0134] Raw Pinellia 80g Licorice Extract 10g Patchouli Oil 0.8ml

[0135] Perilla leaf oil 0.4ml

[0136] Above raw material medicine is made extractum by conventional method;

[0137] The extractum is crushed into fine powder, the extractum of 50g and the effervescent disintegrant of 32g (tartaric acid / sodium bicarbonate=1: 1, sodium bicarbonate is wrapped with 2g polyethylene glycol 6000), 15g of mannitol, 3g The microcrystalline cellulose is granulated with absolute ethanol after mixing, the fluidity of the granules is adjusted by adding 1g of polyvinyl alcohol 6000, adding 1g of menthol for flavoring, tabletting, and effervescent tablets are obtained.

Embodiment 3

[0139] Extract 15g, effervescent disintegrant (sodium carbonate / malic acid=1.2:0.6) 45g, tamarind gum 2g, mannitol 22g, polyvinyl alcohol 60000.6g, peppermint oil 1.2g

[0140] The extract is crushed into fine powder, the extract of the prescribed amount and effervescent disintegrant (sodium carbonate / malic acid=1.2:0.6), mannitol, tamarind gum are mixed, granulated with absolute ethanol, and polyethylene Alcohol 6000 regulates the fluidity of the granules, adds peppermint oil for flavoring, and compresses to make effervescent tablets;

[0141] Wherein extractum is prepared by embodiment 1 method.

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Abstract

The invention discloses an effervescent agent for exterior syndrome relieving and summer heat dispelling and a preparation method thereof. The effervescent agent which comprises an extract prepared from rhizoma atractylodis, dried orange peel, Cortex Magnoliae Officinalis processed by ginger, Dahurica Angelica Root, Poria cocos, Arece Peel, unprocessed Rhizoma Pinelliae, extractum glycyrrhizae, patchouli oil, and perilla leaf oil, and effervescent agent accessories concretely comprises, by weight, 10-150 parts of the extract, 10-50 parts of an effervescent disintegrant (the ratio of an acid source to a CO2 source is 0.5-1.5:0.5-1.5), 1-5 parts of a disintegrant, 5-25 parts of a filling accessory, 0.5-1.5 parts of a flow aid, and 0.5-1.5 parts of a flavoring. The effervescent agent of the invention, which can accelerate the dispersing speed and the dissolving speed of drugs in water, has the characteristics of convenient carrying, stable quality, high biological availability, and rapid drug action, and is especially suitable for exogenous wind cold, internal injury and damp-retention, summer injury and dampness, headache, dizziness, abdominal distention and pain, vomiting, diarrhea, and gastrointestinal type cold.

Description

technical field [0001] The invention relates to an effervescent agent and its preparation method and application, in particular to an effervescent agent for relieving exterior syndrome, dispelling summer heat, transforming symptoms, and neutralizing it, as well as its preparation method and application. Background technique [0002] Cold caused by exogenous wind-cold, internal injury and stagnation of dampness or summer injury and dampness, symptoms include headache, dizziness, fullness of chest and diaphragm, abdominal pain, vomiting and diarrhea; gastrointestinal cold sees the above syndromes. This summer-wet cold causes certain influence to people's work, study and life. Doctor trained in Western medicine has no specific treatment method for this disease, just adopts conventional cold treatment method, and the effect is not obvious at all. Traditional Chinese medicine uses the methods of dispelling heat, relieving the exterior, dispelling dampness and harmonizing the mid...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/889A61K9/46A61P1/08A61P1/12A61P1/14A61P25/04
Inventor 付立家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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