Medicinal composition for treating erectile dysfunction (ED), its preparation method and preparations

A composition and drug technology, applied in the direction of drug combination, medical formula, medical preparations containing active ingredients, etc., can solve the problems of insufficient process, no preparation method, etc., achieve remarkable curative effect, increase the extraction rate of medicinal materials, The effect of high content of active ingredients

Active Publication Date: 2012-04-04
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the above-mentioned processes are not perfect enough, and a set of overall effective preparation methods are not given to obtain a drug extract with high active ingredients.

Method used

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  • Medicinal composition for treating erectile dysfunction (ED), its preparation method and preparations
  • Medicinal composition for treating erectile dysfunction (ED), its preparation method and preparations
  • Medicinal composition for treating erectile dysfunction (ED), its preparation method and preparations

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] Embodiment 1: the preparation of capsule

[0105] 725g of Tribulus terrestris, 45g of Bupleurum, 45g of Earthworm, 46g of hive, 30g of leech, 25g of Nine Fragrance Insect, 10g of Zishaohua, 150g of Cnidium, 75g of Polygala, 50g of Cistanche, 50g of Dodder, 30g of Schisandra, 20g of Morinda officinalis, 30g of centipede , Shichangpu 30g

[0106] The preparation process is:

[0107] (1) Dry Tribulus terrestris, Bupleuri, Polygala, Schisandra chinensis, and leeches respectively at 60-80°C for 6 hours, crush them into coarse powder, pass through a 24-mesh sieve, and set aside;

[0108] (2) Mix the coarse powder of Tribulus terrestris, Bupleurum bupleuri, and Polygala evenly, add 10 times the amount of 70% ethanol to soak for 2 hours, heat and reflux 3 times, each extraction time is 3 hours, and the amount of ethanol used for the second and subsequent times is the medicinal material 10 times the weight, filter, combine the filtrates, concentrate the filtrates to a relative...

Embodiment 2

[0113] Example 2: Preparation of Tablets (Highest Quantity)

[0114] 950g of Tribulus terrestris, 80g of Bupleurum, 80g of earthworm, 80g of beehive, 60g of leech, 50g of chrysanthemum, 30g of purple shoot flower, 200g of cnidium, 90g of polygala, 80g of Cistanche, 80g of dodder, 50g of schisandra, 50g of Morinda officinalis, 80g of centipede , Shichangpu 50g;

[0115] The preparation process is:

[0116] (1) Dry Tribulus terrestris, Bupleuri, Polygala, Schisandra, and leech at 70°C for 6 hours, crush them into coarse powder, pass through a 50-mesh sieve, and set aside;

[0117] (2) Mix the coarse powder of Tribulus terrestris, Bupleuri and Polygala evenly, add 15 times the amount of 60% ethanol to soak for 2 hours, heat and reflux 4 times, each extraction time is 2 hours, and the amount of ethanol used for the second and subsequent times is the medicinal material 8 times the weight, filter, combine the filtrate, concentrate the filtrate to a relative density of 1.10-1.15 at...

Embodiment 3

[0122] Example 3: Granules (minimum amount)

[0123] 400g of Tribulus terrestris, 10g of Bupleurum chinensis, 10g of earthworm, 10g of beehive, 10g of leech, 10g of chrysanthemum, 5g of purple shoot flower, 100g of cnidium, 40g of polygala, 10g of cistanche, 10g of dodder, 10g of schisandra, 10g of Morinda officinalis, 20g of centipede , Shichangpu 10g

[0124] The preparation process is:

[0125] (1) Dry Tribulus terrestris, Bupleurum bupleuri, Polygala, Schisandra chinensis, and leech respectively at 40-80°C for 5 hours, crush them into coarse powder, pass through a 24-mesh sieve, and set aside;

[0126] (2) Mix the coarse powder of Tribulus terrestris, Bupleuri and Polygala evenly, add 5 times the amount of 80% ethanol to soak for 1 hour, heat and reflux 4 times, each extraction time is 5 hours, and the amount of ethanol used for the second and subsequent times is the medicinal material 8 times the weight, filter, combine the filtrate, concentrate the filtrate to a relati...

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Abstract

The invention discloses a medicinal composition for treating ED and its preparation method. Directed at the defects in existing preparation technologies of yang invigorating medicinal compositions, the method of the invention comprises: subjecting tribulus terrstris, radix bupleuri and polygala tenuifolia to heating and backflow with ethanol, then passing the extract through a macroporous adsorption resin column so as to effectively remove a lot of tannins, proteins and other impurities in medicines and reduce the loss late of the active ingredient alkaloid in the medicines, thus enabling more comprehensive refining and more refined extraction; conducting extraction to the five medicinal materials of morinda officinalis, cuscuta chinensis, cistanche, nidus vespae, and lumbricus with ethanol, then carrying out water decoction to the herb residue as well as extraction so as to effectively extract saccharides and other effective components with great polarity from the medicinal materials, thus having high medicine extraction rate, saving cost, and enhancing effect; dipping the four medicinal materials of aspongopus, freshwater sponge, acorus gramineus, and centipedes with ethanol, then performing percolation extraction, thus effectively avoiding the defect of impurity introduction caused by adding medicinal materials directly. The medicinal composition prepared by the extraction method in the invention for treating ED has stable extraction process, simple procedure, suitability for large scale industrial production, high effective component content, higher bioavailability and obvious efficacy. The invention also discloses medicinal preparations which contain the above medicinal composition and treat ED as well as a preparation method thereof.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating impotence, a preparation method and a preparation thereof, and belongs to the field of traditional Chinese medicines. Background technique [0002] Male sexual dysfunction is a common disease, mostly in middle-aged and elderly people. In recent years, with the acceleration of the pace of social life, people's pressure is increasing, and the impact on male sexual function is becoming more and more obvious. Male sexual dysfunction tends to become younger. According to survey data, about 80 million men over the age of 40 in my country suffer from different degrees of male erectile dysfunction, and the prevalence rate of men aged 30 to 40 has increased by 10% compared with ten years ago. On the other hand, male impotence is a manifestation of men's pursuit of a higher quality of life. [0003] From the point of view of Western medicine, impotence (ED) refers to erectile dysfunction of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61P15/10A61K35/56A61K35/62A61K35/64A61K35/648
Inventor 窦啟玲周黎亚彭雯
Owner GUIZHOU YIBAI PHARMA CO LTD
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