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Process to form a tablet and apparatus suitable for applying this process

A technology of tablets and preparations, applied in the field of preparing rapidly disintegrating tablets containing drugs, which can solve problems such as fluid loss

Active Publication Date: 2012-04-11
INTERVET INT BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the disadvantage is that a cooling-heating cycle must be performed to use this method, and the whole process is relatively slow
Furthermore, there is a risk of fluid loss from the cavity when filling with (low viscosity) fluid formulations

Method used

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  • Process to form a tablet and apparatus suitable for applying this process
  • Process to form a tablet and apparatus suitable for applying this process
  • Process to form a tablet and apparatus suitable for applying this process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Example 1 Obtaining tablets containing vaccine components

Embodiment 2

[0058] Example 2 Obtaining tablets containing chemical drugs

Embodiment 3

[0059] Example 3 Determination of the mechanical stability of tablets

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Abstract

The present invention pertains to a process for the preparation of a fast-disintegrating tablet (30) containing a medicinal substance, comprising the steps of providing a fluid formulation comprising the medicinal substance, providing a solid element (100) having formed therein at least one cavity, (101) cooling the solid element (100) to a temperature below a freezing temperature of the formulation, filling the cavity with the fluid formulation, solidifying the formulation while present in the cavity (101) to form a solid pellet comprising the medicinal substance without actively shaping the entire surface of the pellet, taking the pellet out of the cavity and drying the pellet in a vacuum to obtain the tablet. The invention also pertains to a system for performing such a process and a package containing the resulting tablet.

Description

[0001] General invention field [0002] The present invention relates to a method for preparing fast disintegrating tablets containing drugs. Background of the invention [0003] The method for preparing fast-disintegrating tablets (also referred to as "disintegrating tablets" in this specification) is known, for example, from US 5,384,124 to Farmalyoc. In the known method, a paste containing one or more drugs is formed, and the paste is mechanically divided into a cavity having a predetermined shape and size by distributing the paste into a cavity having a predetermined shape and size. For unit doses, these cavities are present in the polyvinyl chloride carrier element. After dispensing the batter, the carrier element is placed in a freeze dryer and the batter is freeze-dried. In this way, each unit dose is formed into a tablet. The advantage of the freeze-drying method is not only to carry the drug in a very stable form, but also to obtain a solid dosage form that disintegrate...

Claims

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Application Information

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IPC IPC(8): A61J3/06A61K9/00A61K9/20F26B5/04
CPCA61J3/06F26B5/06A61K9/2095A61K9/0056
Inventor H·A·米德尔比克J·A·C·斯密特
Owner INTERVET INT BV