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Preparation method of hemostatics and clinopodium polycephalum preparation and quality control technology

A technology of cutting off blood flow and hemostatic drugs, which is applied in the fields of medical formula, pill delivery, blood diseases, etc. It can solve the problems of easy moisture absorption, poor stability, and large dosage, so as to reduce production costs, improve medication compliance, The effect of reducing the expenditure of insurance costs

Inactive Publication Date: 2012-05-09
ANHUI AN TECH MEDICAL & BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, patients often have a reaction to taking a large amount (4-6 tablets each time, 3 times a day), which affects its use, and it is easy to absorb moisture and has poor stability.

Method used

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  • Preparation method of hemostatics and clinopodium polycephalum preparation and quality control technology
  • Preparation method of hemostatics and clinopodium polycephalum preparation and quality control technology
  • Preparation method of hemostatics and clinopodium polycephalum preparation and quality control technology

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Comparison scheme
Effect test

example 1

[0011] 1 prescription

[0012] Cut off blood flow 6750g

[0013] Starch 48g

[0014] Dextrin 9g

[0015] Talc powder 42g

[0016]

[0017] Made into 1000 pieces

[0018] 2 method

[0019] Take 6750g of cutoff blood flow, cut it into sections, add 6 times the amount of water to decoct twice, 1.5 hours each time, combine the decoction, filter, concentrate the filtrate to a relative density of 1.15 (80°C), add ethanol to make the alcohol content reach 75%, fully stirred, let stand for 24 hours, take the supernatant, concentrate under reduced pressure to thick paste, dry under reduced pressure (80 ℃) to dry extract, add starch 48g, dextrin 9g, talcum powder 34g, use 85 % ethanol to make granules, dry, granulate, add 8g of talcum powder, press into 1000 pieces, film-coated, to get final product.

example 2

[0021] 1 prescription

[0022] Cut off blood flow 6750g

[0023] Microcrystalline Cellulose 60g

[0024] Talc powder 40g

[0025]

[0026] Made into 1000 pieces

[0027] 2 method

[0028] Take 6750g of cutoff blood flow, cut it into sections, add 6 times the amount of water to decoct twice, 1.5 hours each time, combine the decoction, filter, concentrate the filtrate to a relative density of 1.15 (80°C), add ethanol to make the alcohol content reach 75%, fully stirred, let stand for 24 hours, take the supernatant, concentrate under reduced pressure to a thick paste, dry under reduced pressure (80 ℃) into dry extract, crush into extract powder, add microcrystalline cellulose 60g, talc 40g of powder is made into granules with 85% ethanol, dried, granulated, and packed into capsules.

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Abstract

The invention relates to a key technology of a new preparation method of a hemostatics oral solid preparation, i.e. the alcohol concentration can be improved to 75% through comparatively analyzing the active ingredients of total saponins and total flavone, so the inactive ingredients can be removed; and the new preparation method can reduce the dose of each time to 2-3 dose units, the amplitude is reduced by 50%, so the medication compliance of patients is greatly improved, and the production and medication costs of the patients are greatly reduced. The method can be used for preparing clinopodium polycephalum tablets, capsules, particles, soft capsules and pills.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a preparation process and quality control technology of a traditional Chinese medicine for stopping blood flow. Background technique [0002] Traditional Chinese medicine believes that blood syndrome starts from the pathogenesis of two aspects: hot fumigation and qi deficiency, and fiery fumigation and forced blood are the early and common symptoms of bleeding syndrome. "Jingyue Quanshu Blood Syndrome" says: "Blood is based on yin essence, and it is not easy to Movement is also, and movement is disease. Blood mainly operates qi, and it is not easy to be damaged, but damage is disease. Most of the movement is caused by fire, and the fire will force the blood to act indiscriminately; the damage is mostly due to qi, and the blood will not be injured In order to survive." This symptom can achieve the purpose of hemostasis from the aspect of cooling blood. There are three...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61K9/20A61K9/48A61P7/04A61P15/00
Inventor 余世春
Owner ANHUI AN TECH MEDICAL & BIOLOGICAL TECH
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