Measurement method of content of 5-hydroxymethylfurfural (5-HMF) in injection

A technology of hydroxymethyl furfural and a determination method, which is applied in the detection field of traditional Chinese medicine injections, can solve problems such as exceeding the standard, poor control or poor process control, and achieves the effect of a simple and convenient method
CN102466658AActive Publication Date: 2012-05-23TIANJIN TASLY ZHIJIAO PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
TIANJIN TASLY ZHIJIAO PHARMA
Publication Date
2012-05-23

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Abstract

The invention relates to a measurement method of content of 5-hydroxymethylfurfural (5-HMF) in an injection. The measurement method comprises the following steps of: (1) pre-processing the injection to obtain a sample solution; (2) preparing a 5-HMF reference solution; (3) measuring the sample solution and the reference solution by adopting a high performance liquid chromatography (HPLC); and (4) calculating the content of the 5-HMF in the sample solution, wherein the preprocessing step comprises the procedure of passing through macroporous adsorption resin.
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Description

technical field

[0001] The invention relates to a method for detecting traditional Chinese medicine injections, in particular to a method for determining the content of 5-hydroxymethylfurfural in injections. Background technique

[0002] 5-Hydroxymethylfurfural (also known as 5-hydroxymethyl-2-furfural, hydroxymethylfurfural, 5-hydroxymethylfurfural or 5-hydroxymethyl-2-furfural), English name 5-hydroxymethyl- 2-furfural, 5-hydroxymethyl-furfural, or 5-HMF, is a chemical substance.

[0003] Injections, especially those containing sugar, often contain impurity 5-hydroxymethylfurfural. Some traditional Chinese medicine injections may also contain 5-hydroxymethylfurfural as an impurity due to sugar substances. The reason is that Chinese medicine extracts contain a large amount of sugar substances. Fructose, glucose and other sugar substances are easy to dehydrate under high temperature, and further produce 5-Hydroxymethylfurfural and polymers may cause allergies and irritatio...

Claims

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