Application of novel stable prulifloxacin mesylate in preparing anti-infectives

A drug and a new technology are applied in the application field of preparing an anti-bacterial infection drug, which can solve the problems of difficult clinical treatment of bacterial drug resistance and the like
CN102475704AActive Publication Date: 2012-05-30HANGZHOU GUOGUANG PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HANGZHOU GUOGUANG PHARMA
Publication Date
2012-05-30

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Abstract

Prulifloxacin has low bioavailability due to poor water solubility. The invention relates to a novel prulifloxacin mesylate and a preparation thereof, a kit comprising an antibiotic preparation of the novel prulifloxacin mesylate, and application of the novel prulifloxacin mesylate in preparing an anti-bacterial infection medicine. Specifically, the invention particularly relates to a novel preparation for injection of a medicine, with a chemical name of 6-fluoro-1-methyl-7-[4-(5-methyl-2-oxo-1,3-dioxole-4-yl)-methyl-1-piperazinyl]-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-mesylate, which can be stably stored. Prulifloxacin is directly injected for administration in the form of thiabutyldine quinoline mesylate, so that the solubility, bioavailability and curative effect of prulifloxacin are improved.
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Description

Technical field:

[0001] The present invention relates to a new prulifloxacin mesylate and its preparation, a kit containing the pharmaceutical antibiotic preparation, and an application of the new prulifloxacin mesylate in preparing an antibacterial infection drug. Specifically, it particularly relates to a new chemical name for injection that can be stored stably: 6-fluoro-1-methyl-7-[4-(5-methyl-2-oxo-1,3-di Oxol-4-yl)-methyl-1-piperidinyl]-4-oxo-4H-[1,3]thiazetidino[3,2-a]quinoline- Pharmaceutical preparations of 3-mesylate. Background technique:

[0002] Microbial infection is the main factor that threatens human health. In the process of fighting against diseases, humans have discovered a variety of antibacterial drugs: β-lactams, macrolides, aminoglycosides, other antibiotics and synthetic drugs. Synthetic drugs include the largest class of antibacterial drugs: quinolones, among which ciprofloxacin, ofloxacin, levofloxacin, pefloxacin, etc. have been widely used in c...

Claims

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