Preparation method of stable prulifloxacin mesylate

The technology of prulifloxacin and mesylate is applied in the application field of preparing an antibacterial infection drug, which can solve the problems of difficult clinical treatment of bacterial drug resistance, and achieve high antibacterial activity and high bioavailability. , the effect of broad antibacterial spectrum
CN102475704BActive Publication Date: 2013-07-10HANGZHOU GUOGUANG PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HANGZHOU GUOGUANG PHARMA
Publication Date
2013-07-10

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Abstract

Prulifloxacin has low bioavailability due to poor water solubility. The invention relates to a novel prulifloxacin mesylate and a preparation thereof, a kit comprising an antibiotic preparation of the novel prulifloxacin mesylate, and application of the novel prulifloxacin mesylate in preparing an anti-bacterial infection medicine. Specifically, the invention particularly relates to a novel preparation for injection of a medicine, with a chemical name of 6-fluoro-1-methyl-7-[4-(5-methyl-2-oxo-1,3-dioxole-4-yl)-methyl-1-piperazinyl]-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-mesylate, which can be stably stored. Prulifloxacin is directly injected for administration in the form of thiabutyldine quinoline mesylate, so that the solubility, bioavailability and curative effect of prulifloxacin are improved.
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Description

technical field

[0001] The present invention relates to a new prulifloxacin mesylate and its preparation, a kit containing the pharmaceutical antibiotic preparation, and an application of the new prulifloxacin mesylate in preparing an antibacterial infection drug. Specifically, it particularly relates to a new chemical name for injection that can be stored stably: 6-fluoro-1-methyl-7-[4-(5-methyl-2-oxo-1,3-di Oxol-4-yl)-methyl-1-piperidinyl]-4-oxo-4H-[1,3]thiazetidino[3,2-a]quinoline- Pharmaceutical preparations of 3-mesylate. Background technique

[0002] Microbial infection is the main factor that threatens human health. In the process of fighting against diseases, humans have discovered a variety of antibacterial drugs: β-lactams, macrolides, aminoglycosides, other antibiotics and synthetic drugs. Synthetic drugs include the largest class of antibacterial drugs: quinolones, among which ciprofloxacin, ofloxacin, levofloxacin, pefloxacin, etc. have been widely used in cli...

Claims

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