Medicinal composition and application thereof

A composition and extract technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., to achieve the effect of reducing blood sugar concentration, improving blood rheological characteristics, and increasing HDL content

Inactive Publication Date: 2013-10-16
GUIZHOU NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing technology can not provide a complete scientific basis to predict whether the combination of traditional Chinese medicine is reasonable
[0006] So far, there has been no report on the combined application of Erigeron breviscapus and Dewweed in the prevention and / or treatment of diabetes and its complications

Method used

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  • Medicinal composition and application thereof
  • Medicinal composition and application thereof
  • Medicinal composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1 of the present invention: preparation of pharmaceutical composition I

[0041] Take 5kg of whole herb of Erigeron breviscapine, crush it, add about 15 liters of 70% alcohol, subject to submerging the medicinal material and slightly higher, heat and reflux for 1 hour, pour out the liquid, continue to add an appropriate amount of 70% alcohol, repeat the same operation, and extract 3 times, the last time the dregs are filtered. Combine the filtrates, concentrate under reduced pressure at 40-60°C to a volume of about 5 liters, dilute the concentrated solution with water to 10 liters, filter, and remove the filter residue. The filtrate was adsorbed and partitioned on the pretreated AB-8 macroporous adsorption resin column, firstly eluted with 30 liters of water, and then eluted with 20 liters of 80% alcohol. Concentrate the 80% alcohol eluate to about 1 liter, adjust the pH value to about 7.0 with 10% sodium hydroxide solution, and spray dry to obtain brown yel...

Embodiment 2

[0044] Embodiment 2 of the present invention: preparation of pharmaceutical composition II

[0045] Take 5kg of whole herb of Erigeron breviscapine, crush it, add about 15 liters of 70% alcohol, whichever is submerged and slightly higher than the medicinal material; heat and reflux for 1 hour, pour out the liquid, continue to add an appropriate amount of 70% alcohol, repeat the same operation, and extract 3 times, the last time the dregs are filtered. Combine the filtrates, concentrate under reduced pressure at 40-60°C to a volume of about 5 liters, dilute the concentrated solution with water to 10 liters, extract and degrease with No. 120 gasoline, extract the water layer with ethyl acetate for 3-4 times, combine the ethyl acetate part, Concentrate under reduced pressure to remove ethyl acetate to obtain a brownish yellow powder C (that is, the extract of Erigeron breviscapine), with a yield of 138 g and a yield of 2.76% (based on the raw material of the whole herb of Erigero...

Embodiment 3

[0048] Embodiment 3 of the present invention: the application of pharmaceutical composition I

[0049] Preparation of pharmaceutical tablets: take pharmaceutical composition I 100g, starch 50g, 10% starch slurry 10g and magnesium stearate 2g; after mixing pharmaceutical composition I and starch, add 10% starch slurry to make soft material , passed through a 14-mesh sieve to granulate, dried at a temperature of 70-80°C, passed through a 12-mesh sieve for granulation, mixed with magnesium stearate, pressed into 1000 tablets, and obtained. Each tablet contains medicinal composition I100mg, which can be used for treating or preventing diabetes.

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Abstract

The invention discloses a medicinal composition and application thereof. The medicinal composition is prepared from an erigeron breviscapus extract and a cyanotis arachnoids extract which serve as active ingredients in a weight ratio of (0.1-10):1. The medicinal composition has the effects of reducing blood sugar, regulating blood fat and improving blood hemorheology under the synergistic action of the erigeron breviscapus extract and the cyanotis arachnoids extract, can be used for preparing medicines for treating or preventing diabetes and also can be used for preparing medicines for improving diabetic complications (namely regulating blood fat, improving microcirculation, improving blood hemorheology and the like).

Description

technical field [0001] The present invention relates to a pharmaceutical composition, specifically, a pharmaceutical composition made of Erigeron breviscapus extract and dew grass extract as active ingredients and its application in the preparation of medicines for treating or preventing diabetes, It belongs to the technical field of traditional Chinese medicine. Background technique [0002] Diabetes mellitus is a common endocrine and metabolic disease, and its prevalence is gradually increasing worldwide. In 2009, the prevalence of diabetes in my country reached 9.7%, and my country has become one of the countries with the fastest growing prevalence of diabetes in the world. Type II diabetes is the main type of diabetic patients in my country. When the glucose metabolism is disordered, it is often accompanied by the disorder of fat metabolism and the abnormality of blood rheology, thus causing a variety of diabetic complications. Therefore, controlling sugar and fat meta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61P3/10
Inventor 杨庆雄黄小燕
Owner GUIZHOU NORMAL UNIVERSITY
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