Application of glibenclamide compound in preparation of information therapy medicament, method for preparing information therapy medicament, and novel drug prepared with method

Abstract

The invention discloses an application of a glibenclamide compound in preparation of an information therapy medicament, a method for preparing the information therapy medicament, and a novel drug prepared with the method. The information therapy medicament is not in direct contact with a human body during treatment, the components of the medicament is not consumed, only medicament information is utilized for physical therapy, so that the chemical treatment effect can be achieved, the therapeutic window is enlarged by more than a thousand times, and the side effect of chemical treatment is avoided. After the glibenclamide is used as the information therapy medicament, the content of effective components of the glibenclamide is not changed, so that the glibenclamide can be used as a conventional preparation in chemical treatment for secondary effective use.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a novel drug of glibenclamide. Background technique [0002] The compound Glibenclamide is N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy-5-chlorobenzene Formamide, chemical formula C 23 h 28 CLN 3 o 5 S, molecular weight 491.01. The properties are white crystalline powder, almost odorless and tasteless. Insoluble in water or ether, slightly soluble in chloroform, slightly soluble in methanol or ethanol. The melting point is 170-174°C. Glibenclamide is a hypoglycemic agent clinically used to treat diabetes. The pharmaceutical preparations of glibenclamide include tablets, capsules, etc. The known glibenclamide drugs are all used as chemotherapeutic drugs, which allow the compound glibenclamide molecules to enter the human body (through oral absorption into the blood), distribute to various tissues, and produce through the chemical reaction of drug mo...

AI Technical Summary

Problems solved by technology

In the prior art, glibenclamide has insurmountable defects as a chemotherapeutic drug. The first is its toxic and side effects on the human body, and its nasty adverse reactions include hypoglycemia and severe hypoglycemia. Life-threatening, gastrointestinal nausea and vomiting, loss of appetite, diarrhea, jaundice, abnormal liver function, anemia, thrombocytopenia, allergic reaction, arthralgia, intramuscular pain, vasculitis reaction, etc.; second, the treatment window is small, due to the presence of Toxic and side effects, the effective dose that can be used is very small, which limits the therapeutic effect. The maximum dose of oral administration is 5 mg once, 15 mg a day, and poisoning can be caused if it exceeds the maximum dose; Once it enters the human body, it will be metabolized or excreted and cannot be used again

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