Traditional Chinese medical composition used for treatment of vascular dementia and preparation and application thereof

A technology of vascular dementia and composition, which is applied in the field of traditional Chinese medicine composition for treating vascular dementia and its preparation, and can solve problems such as high price, inaccurate curative effect, and large side effects

Inactive Publication Date: 2012-07-18
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, Western medicines for treating vascular dementia include cholinesterase inhibitors, calcium antagonists, neuropeptides and nerve growth factors, etc., but the curative effect is not yet clear, and the price is relatively expensive, and some medicines have serious side effects

Method used

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  • Traditional Chinese medical composition used for treatment of vascular dementia and preparation and application thereof
  • Traditional Chinese medical composition used for treatment of vascular dementia and preparation and application thereof
  • Traditional Chinese medical composition used for treatment of vascular dementia and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The preparation method of embodiment 1 granule

[0037] (1) Weigh the medicinal flavors of the preparation, steam distill Yizhi (1kg) (Alpinia oxyphylla Miq.) blindly, extract 25mL of volatile oil, and set aside; Thunb.), Zhiyuanzhi (0.9kg) (Polygala tenuifolia Willd.), Chuanxiong (1kg) (Ligusticum chuanxiong Hort.), Zhizhi leech (1kg) (Whitmania pigra Whitman), borneol (0.1kg), mix the five flavors, add water and fry Boil twice, measure 10 times of water for the first time, 8 times of water for the second time, decoct for 1.5 hours each time, filter the extract, and set aside; the above two water extracts are concentrated to a relative density of 1.05-1.09, and the % ethanol precipitation until the alcohol content reaches 70% vt;

[0038] (2) The alcohol precipitation supernatant is concentrated to a relative density of 1.02 to 1.10 by a vacuum film;

[0039] (3) The concentrated solution is spray-dried into a dry powder (920g);

[0040] (4) 25mL of volatile oil is ...

Embodiment 2

[0042] Embodiment 2: the preparation method of capsule

[0043] Weigh each medicinal flavor of the preparation, add Yizhi (1kg) (Alpinia oxyphylla Miq.) to 12L of water, steam distill for 5h to extract the volatile oil, filter the extract, and set aside; Combined for 3.0 hours, the clathrate was obtained and set aside; after the oil was extracted, the medicinal residues were mixed with Radix Polygoni Multiflori (1kg) (Polygonum mnltiflorum Thunb.), Zhiyuanzhi (0.9kg) (Polygala sibirica L.), Chuanxiong (1kg) (Ligusticum chuanxiong Hort. ), broiled leech (1kg) (Hirudo Nipponica Whitman), borneol (0.1kg) mixed with the five flavors, add water to decoct twice, add 60L for the first time, decoct for 2h, add 50L for the second time, decoct for 1.5h , after filtering the water extract, concentrate under low temperature and reduced pressure (-0.085Mpa, 70-80°C) to a relative density of 1.05-1.09 (60°C), let cool to room temperature, and slowly add ethanol to make the alcohol content rea...

Embodiment 3

[0044] Embodiment 3: the preparation method of tablet

[0045] (1) Weigh the medicinal flavors of the preparation, steam distill Yizhi (1kg) blindly, extract the volatile oil, and set aside; 0.9kg) (Polygala tenuifolia Willd), Chuanxiong (1kg) (Ligusticum chuanxiong Hort.), broiled leech (1kg) (Whitmania acranulata Whitman), borneol (0.1kg), after mixing the five flavors, add water to decoct, filter the extract, and set aside ; The above two water extracts are concentrated to a relative density of 0.05 to 0.08, and refined by a membrane process to obtain a refined water extraction solution;

[0046] (2) The above-mentioned water-extracted refined solution is concentrated to a relative density of 1.02 to 110;

[0047] (3) The concentrated solution is spray-dried into a dry powder;

[0048] (4) The volatile oil is clathrated with β-cyclodextrin;

[0049] (5) Mix the above dry powder and β-cyclodextrin evenly, add appropriate amount of excipients and mix evenly, dry granulate,...

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Abstract

The invention relates to a traditional Chinese medical composition used for treatment of vascular dementia and a preparation and application thereof. The traditional Chinese medical composition is prepared with the following components by mass: 20-50 parts of polygonum multiflorum, 15-50 parts of alpinia oxyphylla, 15-50 parts of prepared polygala tenuifolia, 10-15 parts of prepared leech, 10-40 parts of ligusticum wallichii and 1-3 parts of borneol. The preparation method comprises: extracting medicinal materials respectively with water vapor and in a boiling method, using ethanol for precipitation after filtration of water extract, and decompressing and concentrating ethanol extract, spraying, drying, adding additives and carrying out dry granulation to prepare particles, capsules and tablets; and adding additives, adding water for dilution, and preparing orally taken solution, admixture and water aqua. 31 preliminary clinical tests show that the efficacy is obvious, the curing efficiency is 22.6 percent, the total efficiency is 80.6 percent and is significantly higher than 8 percent and 56 percent of piracetam control groups, and P is less than 0.05.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating vascular dementia, a preparation method and application thereof. Background technique [0002] Domestic and foreign studies have shown that with the aging of the population, the incidence and prevalence of dementia are gradually increasing. The prevalence of dementia in the elderly over 80 years old is as high as 20%, which has a serious impact on human life and health. [0003] Vascular dementia (VAD) is a mental retardation disease caused by cerebrovascular damage caused by cerebrovascular factors, mainly due to cerebral arteriosclerosis, cerebral infarction, etc., which lead to cerebral circulation disorder and global cerebral ischemia, reducing the function of brain tissue. It is clinically seen in multi-infarct dementia (MID), lacunar dementia, cerebral hemorrhage, and dementia caused by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9062A61K9/16A61K9/20A61K9/48A61K9/00A61P9/10A61P25/28
Inventor 过伟峰朱华旭李璘卞慧敏孙蓉蓉李婷婷
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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