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Gynostemma pentaphylla secondary saponin, preparation method and applications thereof

A technology of Gynostemma Gynostemma saponin and Gynostemma pentaphyllum, applied in the field of Gynostemma pentaphyllum, can solve the problems such as the patent report of Gynostemma Gynostemma secondary saponin that has not been seen against cancer, and achieve the effects of less side effects, simple equipment condition requirements, and simple process flow

Inactive Publication Date: 2012-07-25
厦门华侨亚热带植物引种园
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

According to literature and patent retrieval, there is no patent report on the preparation of Gypenosides with anticancer activity by microbial transformation method

Method used

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  • Gynostemma pentaphylla secondary saponin, preparation method and applications thereof
  • Gynostemma pentaphylla secondary saponin, preparation method and applications thereof
  • Gynostemma pentaphylla secondary saponin, preparation method and applications thereof

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Embodiment Construction

[0033] The present invention will be described in further detail below in conjunction with the accompanying drawings.

[0034] The invention utilizes a biotransformation method to prepare gypenosides secondary saponins, mainly including preparation of gypenosides, microbial conversion of gypenosides and preparations of gypenosides secondary saponins. The following provides examples of Aspergillus niger and Aspergillus nidulans preparing Gypenoside secondary saponins, while providing separation and purification of transformation products, compound structure identification, and utilizing the MTT method to detect the inhibitory effect of secondary saponins on liver cancer cells to further illustrate the present invention, but not It does not mean that the present invention is limited to this example.

[0035] The material selected in the present invention is Gynostemma pentaphyllum in the planting area of ​​Nanjing, Fujian, which is a disclosed biological material.

[0036] The ...

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Abstract

The invention discloses gynostemma pentaphylla secondary saponin, a preparation method of the gynostemma pentaphylla secondary saponin and applications of the gynostemma pentaphylla secondary saponin, and relates to gynostemma pentaphylla. The name of a compound of the gynostemma pentaphylla secondary saponin is 2Alpha, 3Beta, 12Beta, 20(S)-tetrahydroxy-24-dammarene-3-O-Beta-D-glucopyranose-(1--2)-Beta-D- glucopyranoside. Gynostemma pentaphylla saponin is prepared and is converted by microbe, and the gynostemma pentaphylla secondary saponin is prepared. By the antitumor activity determination of the compound, the gynostemma pentaphylla secondary saponin is proved to be used for preparing an antitumor activity agent. The gynostemma pentaphylla secondary saponin is prepared by a microbial conversion method, and the gynostemma pentaphylla is taken as raw materials, is planted in a large area in China, is low in cost and easy to obtain, and rich in resources, so that the gynostemma pentaphylla secondary saponin is a good material for developing and applying biological medicines and health care products; the process steps are simple, macroporous adsorption resin is adopted as a main preparation filler, and the gynostemma pentaphylla secondary saponin is suitable for scale amplification; and compared with a chemical acid-base cracking method, the preparation method has the advantages that the requirements for equipment conditions are simple, and the side effects of the prepared product is little.

Description

technical field [0001] The invention relates to Gynostemma pentaphyllum, in particular to a secondary saponin of Gynostemma pentaphyllum and its preparation method and application. Background technique [0002] Gynostemma pentaphyllum Thnmb Mak. is a plant of the genus Gynostemma cucurbitaceae. The main medicinal ingredient of Gynostemma pentaphyllum is gypenoside (GYP), which has the functions of inhibiting tumors, preventing aging, lowering blood lipids, enhancing immunity, protecting the heart and liver, and lowering blood sugar. , sedative pain relief and anti-ulcer pharmacological effects. Gypenoside has the reputation of "Southern Ginseng" and "Second Ginseng" because it has a dammarane-type structure with a main skeleton similar to ginsenoside. [0003] In recent years, through the study of pharmacodynamics and metabolic kinetics of saponin physiological activity, it has been noticed that there is a close relationship between the sugar chain in saponin and its biolog...

Claims

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Application Information

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IPC IPC(8): C07J17/00C12P33/20A61P35/00C12R1/66C12R1/685
Inventor 陈良华童庆宣明艳林郑志忠郑国华
Owner 厦门华侨亚热带植物引种园
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