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Oral compositions for treating tooth sensitivity and methods of use and manufacture thereof

A composition and polymer technology, applied in the field of preventing or alleviating tooth sensitivity, can solve problems such as time-consuming and wasteful

Active Publication Date: 2012-08-01
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The user typically needs to agitate the paint to mix the phases, which is time consuming and wasteful as the paint sticks to the mixing equipment and is subsequently discarded

Method used

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  • Oral compositions for treating tooth sensitivity and methods of use and manufacture thereof
  • Oral compositions for treating tooth sensitivity and methods of use and manufacture thereof
  • Oral compositions for treating tooth sensitivity and methods of use and manufacture thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0139] Suitable bioadhesive polymers include PEG / PPG copolymer (BASF Pluracare L1220), polyvinylmethyl ether / maleic acid copolymer (Gantrez, ISP), cross-linked PVP (crospovidone, ISP), Shellac (R49 shellac, Mantrose-Hauser) and ester gum (Eastman Chemicals). Occlusive agents for desensitization that can be used in formulations include bioactive glass, arginine / calcium carbonate, arginine bicarbonate / calcium carbonate (Cavistat / PCC), and small particle silica or combinations of these substances.

[0140] An example of a suitable small particle silica includes Sorbosil AC43 from Ineos. Table 1 below sets forth illustrative examples of compositions with bioactive glass and resulting pH.

[0141] Table 1

[0142]

Control

A

B

C

D

Element

weight%

weight%

weight%

weight%

weight%

Glycerin

25

25

Pluracare L1220

40

25

25

Pluracare L4370

...

Embodiment 2

[0152] Example 2 - Single Tube Toothpaste Product Containing Occlusives and Potassium Salts Providing Excellent Tooth Sensitivity Relief

[0153] One illustrative embodiment of the invention encompasses a single tube toothpaste product comprising one or more inclusion agents and one or more potassium salts. In one illustrative embodiment, a single tube technique combining a rapid occlusive agent (eg, a bioactive and bioacceptable glass (eg, novamin)) with potassium is contemplated in order to deliver more rapid relief. A non-aqueous bioactive and bioacceptable glass formulation with potassium was found to provide significant in vitro occlusion.

[0154] In another illustrative embodiment, it was surprisingly found that the formulation of the bioactive and bioacceptable glass (e.g. Novamin) has additional Occlusion benefit.

[0155] image 3 In vitro dose-response studies are described, which were performed to determine optimal bioactive and bioacceptable levels of glass (eg...

Embodiment 6

[0163] exist Figure 5 A set of conduction data with 10% Novamin toothpaste versus a conventional non-occlusive silica toothpaste control is illustrated in , and confocal laser microscopy images showing Novamin dose-response and potentiating effects of AC43 silica. The top line represents the novamin sample and the bottom line represents the control sample.

[0164] average conduction

[0165]

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Abstract

The invention encompasses oral care compositions comprising one or more active component and one or more adhesive polymers, which cause the active component to adhere to the tooth surface. In certain embodiments the active agent is an occlusion agent. The invention also encompasses methods of treating the teeth or a teeth surface with an active agent. In certain embodiments, the invention encompasses treating the teeth with an occlusion agent to prevent or alleviate tooth sensitivity.

Description

field of invention [0001] The present invention encompasses oral care compositions comprising one or more active ingredients and one or more bioadhesive polymers which promote adhesion of the active ingredients to tooth surfaces. In certain embodiments, the active agent is an occlusion agent. The present invention also encompasses methods of treating teeth or tooth surfaces with active agents. In certain embodiments, the present invention encompasses treating teeth with occlusive agents to prevent or alleviate tooth sensitivity. Background of the invention [0002] There are some situations where permanent contact of the oral care composition with the teeth is desired. For example, it may be desirable to use active agent levels for prolonged periods of time to treat or prevent eg xerostomia (dry mouth), dental hypersensitivity, dental caries. This can be achieved by using a dental tray, wherein the composition is applied to the tray, and the composition and tray are then ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/25A61K6/884
CPCA61K8/927A61Q11/00A61K8/25A61K8/8164A61K8/86A61K8/375
Inventor L·蔡德尔M·普伦西普S·K·乔普拉
Owner COLGATE PALMOLIVE CO
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