Preparation method of pelvic floor patch composite biological material and product of preparation method

Abstract

The invention discloses a preparation method of a pelvic floor patch composite biological material. The preparation method comprises the specific step of treating accellular matrix gel and a polypropylene material at pressure of at least 100MPa for at least 5 minutes. The preparation method is simple, enables the accellular matrix gel and the polypropylene material to be combined firmly, does not utilize chemical crosslinking agent in a crosslinking process, and is free from chemical residuals. The invention also discloses the pelvic floor patch composite biological material prepared by the method, and application of the material. Animal experiments prove that the material has the advantages of being good in tissue compatibility and being free from inflammatory response and can be used for treating pelvic organ prolapse.

Description

technical field

[0001] The invention relates to the field of materials, in particular to a preparation method of a pelvic floor patch composite biomaterial, and also to a product prepared by the method. Background technique

[0002] Female pelvic organ prolapse is a common disease with a domestic incidence of about 40% and increasing year by year. It has become a major gynecological problem that seriously affects the health and quality of life of middle-aged and elderly women. Polypropylene synthetic material is widely used clinically as a gynecological pelvic floor patch. Although the patch is effective, it has disadvantages such as poor compliance, strong tissue erosion, and high infection rate, and it is easy to cause related complications such as dyspareunia. Studies have shown that the porcine acellular bladder matrix material has good biocompatibility and certain antibacterial properties, and is an ideal gynecological pelvic floor patch. However, porcine acellular bla...

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