Preparation method of pelvic floor patch composite biological material and product of preparation method

A technology for composite biological materials and patches, which is applied in the field of preparation of composite biological materials for pelvic floor patches, can solve the problems of large volume of composite materials, unfavorable operation and clinical use, and difficulty in removing cross-linking agents completely, and achieves a simple preparation method. , No inflammatory reaction, good therapeutic effect

Active Publication Date: 2012-08-15
重庆芳禾生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Acellular bladder matrix / polypropylene / acellular bladder matrix composite biomaterials, compared with pure polypropylene materials, although the inflammatory response is reduced, but the volume of composite materials is relatively large, and the combination of acellular bladder matrix and polypropylene materials is not tight. Not conducive to operation and clinical use
At present, although the use of cross-linking agents to prepare organic / inorganic composite biomaterials can combine the strengths of the two to a certain extent, it is difficult to completely remove the cross-linking agents, and the residues will affect the biological properties of composite biomaterials to a certain extent and cause A range of clinical side effects

Method used

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  • Preparation method of pelvic floor patch composite biological material and product of preparation method
  • Preparation method of pelvic floor patch composite biological material and product of preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation method of the pelvic floor patch composite biological material specifically comprises the following steps:

[0026] A. Preparation of acellular matrix gel

[0027] Take the fresh bladder of the pig, clean it with tap water, and then remove the surface mucous membrane layer to obtain the pig mucous membrane layer-removed bladder;

[0028] Cut the obtained porcine mucosa-removed bladder into small pieces with scissors, rinse it 3 times with pure water, then soak it in disinfectant solution for 15 minutes for disinfection, wherein the disinfectant solution is 0.1% bromogeramine by mass fraction;

[0029] Immerse the sterilized bladder tissue in the degreasing solution, place it at 4°C, and stir it with magnetic force for 16 hours to degrease to obtain the defatted bladder tissue; the degreasing solution is ethanol: isopropanol: water mixed in 7:4:89 ( Volume ratio);

[0030] The obtained defatted bladder tissue was repeatedly washed with ultrapure water ...

Embodiment 2

[0043] The preparation method of the pelvic floor patch composite biological material specifically comprises the following steps:

[0044] A. Preparation of Acellular Matrix Gel

[0045] Take the fresh skin of the pig, clean it with tap water, and then remove the subcutaneous tissue with a slicer to obtain the skin of the pig with the subcutaneous tissue removed;

[0046] The obtained pig subcutaneous tissue skin was cut into small pieces with scissors, washed 5 times with pure water, then soaked in disinfectant for 20 minutes for disinfection, wherein the disinfectant was 0.1% bromogeramine by mass fraction;

[0047] Immerse the obtained sterilized pig skin tissue in the degreasing solution, place it under the condition of 4°C, and degrease with magnetic stirring for 18 hours to obtain the degreasing pig skin tissue; the degreasing solution is ethanol: isopropanol: water according to the ratio of 7:4 : 89 (volume ratio) mixing;

[0048] Wash the obtained defatted pig skin t...

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Abstract

The invention discloses a preparation method of a pelvic floor patch composite biological material. The preparation method comprises the specific step of treating accellular matrix gel and a polypropylene material at pressure of at least 100MPa for at least 5 minutes. The preparation method is simple, enables the accellular matrix gel and the polypropylene material to be combined firmly, does not utilize chemical crosslinking agent in a crosslinking process, and is free from chemical residuals. The invention also discloses the pelvic floor patch composite biological material prepared by the method, and application of the material. Animal experiments prove that the material has the advantages of being good in tissue compatibility and being free from inflammatory response and can be used for treating pelvic organ prolapse.

Description

technical field [0001] The invention relates to the field of materials, in particular to a preparation method of a pelvic floor patch composite biomaterial, and also to a product prepared by the method. Background technique [0002] Female pelvic organ prolapse is a common disease with a domestic incidence of about 40% and increasing year by year. It has become a major gynecological problem that seriously affects the health and quality of life of middle-aged and elderly women. Polypropylene synthetic material is widely used clinically as a gynecological pelvic floor patch. Although the patch is effective, it has disadvantages such as poor compliance, strong tissue erosion, and high infection rate, and it is easy to cause related complications such as dyspareunia. Studies have shown that the porcine acellular bladder matrix material has good biocompatibility and certain antibacterial properties, and is an ideal gynecological pelvic floor patch. However, porcine acellular bla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/16
Inventor 葛良鹏刘禄斌张晓春黄萍
Owner 重庆芳禾生物科技有限公司
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