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External medicament for treating bacterial vaginosis and colpitis mycotica

A technology of fungal vaginitis and topical medicine, applied in the field of plant materials, can solve the problems of poor curative effect, high price, and inconvenient use

Active Publication Date: 2012-09-19
HC SYNTHETIC PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The clinical application of the above-mentioned drugs is limited due to inconvenience in use, inconvenience in carrying, poor curative effect, or high price.

Method used

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  • External medicament for treating bacterial vaginosis and colpitis mycotica
  • External medicament for treating bacterial vaginosis and colpitis mycotica
  • External medicament for treating bacterial vaginosis and colpitis mycotica

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Taking the production of 1000 pharmaceutical suppository products of the present invention as an example, the used Chinese medicine raw materials and auxiliary materials and their proportioning ratio are:

[0035]

[0036] Its preparation method is as follows:

[0037] Phellodendron Phellodendri, Sophora flavescens, Fructus flavescens, Fructus Cnidii and Fructus Cnidii respectively add 5 times, 4 times amount 85% ethanol reflux extraction twice in the proportioning of the present invention, each time 1.5 hours, merge extracts, reclaim ethanol under reduced pressure to No alcohol smell, let stand for 24 hours, discard the sediment, dry under reduced pressure, crush; take suppository base mixed with 1440g of fatty acid glyceride, heat and melt, keep the temperature at 40°C±2°C, add the above-mentioned dry cream powder, and take another borneol, Add a small amount of absolute ethanol to dissolve, add to the matrix, and mix well. Molded, made into 1000 grains, that is. ...

Embodiment 2

[0050] Taking the production of 1000 pharmaceutical suppository products of the present invention as an example, the used Chinese medicine raw materials and auxiliary materials and their proportioning ratio are:

[0051]

[0052] Its preparation process is identical with the preparation process of embodiment 1 suppository. Each grain weighs 2.5g, and each gram contains 3.872g of traditional Chinese medicine raw materials.

[0053] Taking the production of 1000 tablets of the pharmaceutical tablet product of the present invention as an example, the used Chinese medicine raw materials and auxiliary materials and their proportioning ratio are:

[0054]

[0055] Its preparation process is carried out according to the preparation process of the tablet of the present invention. Each piece weighs 1.5g, and each gram contains 6.453g of traditional Chinese medicine raw materials.

[0056] Taking the production of 1000 tablets of the drug effervescent tablet product of the prese...

Embodiment 3

[0064] Taking the production of 1000 pharmaceutical suppository products of the present invention as an example, the used Chinese medicine raw materials and auxiliary materials and their proportioning ratio are:

[0065]

[0066] Its preparation process is identical with the preparation process of embodiment 1 suppository. Each grain weighs 2.5g, and each gram contains 3.872g of traditional Chinese medicine raw materials.

[0067] Taking the production of 1000 tablets of the pharmaceutical tablet product of the present invention as an example, the used Chinese medicine raw materials and auxiliary materials and their proportioning ratio are:

[0068]

[0069]

[0070] Its preparation process is carried out according to the preparation process of the tablet of the present invention. Each piece weighs 1.5g, and each gram contains 6.453g of traditional Chinese medicine raw materials.

[0071] Taking the production of 1000 tablets of the drug effervescent product of the ...

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Abstract

The invention discloses an external medicament for treating bacterial vaginosis and colpitis mycotica. The external medicament is a medicament prepared from Chinese medicinal raw materials including 35-70 parts by weight of amur corktree bark, 30-60 parts by weight of lightyellow sophora root, 30-60 parts by weight of cortex ailanthi, 20-40 parts by weight of polygonum aviculare, 10-35 parts by weight of selinum japenious seed and 1-2.5 parts by weight of borneol according to the conventional preparation method. As proved by a pharmacodynamic test, the medicament has a remarkable in-vitro antibacterial action, and can be used for effectively killing and suppressing common pathogenic bacteria of reproductive tract infection; the medicament has a remarkable treatment effect on rabbit colpitis mycotica; compared with a model control group, a medicament group has the advantages: the vagina cleanliness and curative ratio are increased remarkably, and the pathological feature of rabbit colpitis mycotica can be improved remarkably; the medicament has a remarkable anti-inflammatory effect, and can be used for remarkably relieving dimethyl benzene-caused mouse auricle inflammation, suppressing the formation of mouse granuloma and reducing the mouse abdominal cavity capillary permeability; and the medicament has a certain itching relieving effect.

Description

technical field [0001] The invention belongs to the technical field of medical preparations containing raw materials or their reaction products with unknown structures, and specifically relates to materials derived from plants. Background technique [0002] Bacterial vaginosis is one of the most common vaginal infectious diseases in women of childbearing age. In addition to causing vaginal inflammation, it can also cause many other adverse outcomes, such as: infertility and miscarriage, endometritis, pelvic inflammatory disease, gynecological Postoperative infection, chorioamnionitis, premature rupture of membranes, premature delivery, etc., rank first in the incidence of vaginitis, which is a serious threat to female reproductive health diseases. 80% to 90% of mycotic vaginitis is infected by Candida albicans, and the clinical manifestation is white bean curd residue-like leucorrhea or watery leucorrhea, which brings great pain to patients due to special itching, burning pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61P15/02A61P31/10A61K31/045
Inventor 马耀茹
Owner HC SYNTHETIC PHARMA CO LTD
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