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Compound sodium bicarbonate injection and preparation method thereof

A technology of compound sodium bicarbonate and sodium bicarbonate, which is applied in the fields of blood diseases, medical formulas, and extracellular fluid diseases, etc., can solve problems such as the influence of blood calcium, hypocalcemia, and excess intracellular alkali, and achieve recovery of activity, Restoring substance metabolism and maintaining normal blood calcium

Inactive Publication Date: 2012-10-17
李玉才
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main clinical pharmacological problem of all antacid drugs currently used clinically at home and abroad, including NaHCO3, THAM, Carbicarb and Tribonate, is that they cannot effectively buffer excess intracellular acid ; After medication, it is easy to cause excess alkali in cells, that is, alkalosis; after medication, it is easy to cause severe hypocalcemia
However, it still has the problem that it cannot effectively restore the activity of Na-KATPase in cardiomyocytes, and cannot provide effective protection for damaged cardiomyocytes, especially the problem that it has a greater impact on blood calcium.

Method used

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  • Compound sodium bicarbonate injection and preparation method thereof
  • Compound sodium bicarbonate injection and preparation method thereof
  • Compound sodium bicarbonate injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Compound sodium bicarbonate injection, its raw material composition, and preparation method are as follows: get trisaminomethane 100kg, add the distilled water that accounts for total distilled water 7350 kg, obtain the completely dissolved trisaminomethane solution stand-by; The pH value of methane solution is titrated to 7.8; Get sodium bicarbonate 100kg, add the distilled water that accounts for total distilled water 1764kg, get the fully dissolved sodium bicarbonate solution stand-by; Mix the fully dissolved sodium bicarbonate solution into the trisaminomethane that pH is 7.8 Obtain mixed solution in the solution; 686kg distilled water is joined in the mixed solution; The liquid after mixing is filtered, subpackaged, and after sealing, temperature is 115 ℃, autoclave 30 minutes, acquired.

Embodiment 2

[0019] Compound sodium bicarbonate injection, its raw material composition, and preparation method are as follows: get trisaminomethane 140kg, add the distilled water that accounts for total distilled water 8250 kg, obtain the completely dissolved trisaminomethane solution stand-by; The pH value of methane solution is titrated to 8.0; Get sodium bicarbonate 100kg, add and account for the distilled water of total distilled water 1980kg, get the fully dissolved sodium bicarbonate solution stand-by; Mix the completely dissolved sodium bicarbonate solution into the trisaminomethane that pH is 8.0 Obtain mixed solution in the solution; 770kg distilled water is joined in the mixed solution; The liquid after mixing is filtered, subpackage, after sealing, temperature is 115 ℃, autoclave 30 minutes, acquired.

Embodiment 3

[0021] Compound sodium bicarbonate injection, its raw material composition, and preparation method are as follows: get trisaminomethane 120kg, add the distilled water that accounts for total distilled water 6750 kg, obtain the completely dissolved trisaminomethane solution stand-by; The pH value of methane solution is titrated to 8.1; Get sodium bicarbonate 100kg, add the distilled water that accounts for total distilled water 1620kg, get the fully dissolved sodium bicarbonate solution stand-by; Mix the fully dissolved sodium bicarbonate solution into the trisaminomethane that pH is 8.1 Obtain mixed solution in the solution; 630kg distilled water is joined in the mixed solution; The liquid after mixing is filtered, subpackage, after sealing, temperature is 115 ℃, autoclave 30 minutes, acquired.

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Abstract

The invention relates to a compound sodium bicarbonate injection and a preparation method thereof, belonging to the field of pharmaceutical technology. The compound sodium bicarbonate injection is prepared from the following raw materials in parts by weight: 1 part of sodium bicarbonate, 1 to 1.4 parts of trisaminomethane, 90 to 110 parts of distilled water, and appropriate amount of hydrochloricacid, wherein the dosage of hydrochloric acid can titrate the pH value of the trisaminomethane solution to 7.8 to 8.1. Compared with the prior patent and other published technologies, the method provided by the invention can effectively restore the activity of myocardial cell Na-KATP enzyme, provide protection for the myocardial cell damaged, maintain the normality for the substructure of damagedmyocardial cell normally or close to the normal state, effectively restore the metabolism inside and outside the cell, recover the normal and orderly exchange of K<+>, Na<+> and Ca<2+>, and maintain the normal blood calcium.

Description

technical field [0001] The invention relates to a compound sodium bicarbonate injection and a preparation method thereof, belonging to the technical field of medicines. Background technique [0002] Antacid drugs play an extremely important role in clinical cardiopulmonary cerebral resuscitation, including cardiomyocyte protection, brain cell protection, etc. At present, the clinical use at home and abroad includes NaHCO 3 The main clinical pharmacological problems of all antacid drugs including , THAM, Carbicarb and Tribonate are: they cannot effectively buffer the excess acid in cells; cause severe hypocalcemia. During cardiopulmonary cerebral resuscitation, the induction of severe hypocalcemia will seriously damage the systemic circulation of cardiopulmonary cerebral resuscitation patients, resulting in severe hypotension or systemic circulatory insufficiency, which seriously affects the survival rate of cardiopulmonary cerebral resuscitation patients. Therefore, curre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/00A61K9/08A61P7/08
Inventor 李玉才
Owner 李玉才
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