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Pharmaceutical composition for targeting treatment of intractable epilepsy

A technology for intractable epilepsy and targeted therapy, applied in the field of biomedicine, can solve problems such as uncertainty and achieve the effect of increasing the frequency of seizures

Inactive Publication Date: 2012-10-17
SHANGHAI FIRST PEOPLES HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a result, the researchers were uncertain whether overexpression of Pgp was the true cause of drug resistance, whether it was simply a consequence of uncontrollable seizures, or an epiphenomenon that occurred in the epileptogenic brain tissue , regardless of drug sensitivity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: The inhibitory effect of a pharmaceutical composition containing a small molecular compound or a monoclonal antibody or a viral vector carrying a small interfering RNA on the expression of P-glycoprotein in the frequency and duration of refractory epileptic seizures.

[0020] 1. Experimental animals: A total of 20 female Sprague-Dawley rats weighing 200-230 g were used as experimental animals, which were purchased from Shanghai Experimental Animal Center, Chinese Academy of Sciences.

[0021] 2. Pretreatment of experimental animals:

[0022] Rats were anesthetized by intraperitoneal injection of 1% pentobarbital sodium (40 mg / kg). After the anesthesia was successful, the head of the rat was fixed on a stereotaxic apparatus (Jiangwan Type II). The basolateral nucleus of the amygdala was positioned (AP-2.0mm, ML 5.0mm, VD 8.0mm), and a Teflon bipolar stainless steel electrode with a diameter of 0.2mm was implanted into the basolateral nucleus of the amygdala (B...

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Abstract

The invention belongs to the biological medicine field, and relates to a pharmaceutical composition for targeting treatment of intractable epilepsy, the pharmaceutical composition of the present invention contains a micromolecule compound or a monoclonal antibody or virus vector carrying micromolecule interference RNA, the effective dosage of the micromolecule compound or the monoclonal antibody or the viral vector carrying micromolecule interference RNA in the composition on the P-glycoprotein expression inhibition efficiency can reach 30% or more than 30%, the animal experiment result shows that the effective dosage can perform the effects for inhibiting the epilepsy attack frequency and the attack duration. The corresponding brain wave presents the similar change with the epilepsy attack frequency and the attack duration.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to drugs for targeted treatment of intractable epilepsy, in particular to a drug combination for targeted treatment of intractable epilepsy containing small molecule compounds / monoclonal antibodies / virus vectors carrying small molecule interference RNAs thing. Background technique [0002] In recent years, although great progress has been made in the treatment of antiepileptic drugs (AEDs) and surgery for refractory epilepsy, refractory epilepsy is still an important issue for clinicians. An important feature of patients with refractory epilepsy is resistance to multiple AEDs with different mechanisms of action, suggesting that there may be a non-specific mechanism leading to multidrug resistance in patients with refractory epilepsy, in which multidrug transporters are overexpressed The hypothesis has received extensive attention from researchers in this field. [0003] P-glycoprotein (P-g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K39/395A61K48/00A61K31/713A61P25/08
Inventor 王枫刘振国赵永波
Owner SHANGHAI FIRST PEOPLES HOSPITAL
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