Quality control method for Uighur medicine spikenard strength replenishing preparation

A quality control method and Uyghur technology, applied in measuring devices, color/spectral characteristic measurement, instruments, etc., can solve problems such as hidden dangers in clinical use, incomplete methods, and difficulties in production and operation, and achieve good reproducibility and strong stability , the effect of high sensitivity

Active Publication Date: 2012-10-24
新疆天山莲药业有限公司
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Problems solved by technology

[0002] "Drug Standards of the Ministry of Health of the People's Republic of China" (Uyghur medicine sub-volume) announced a Songbuli preparation that has the effects of nourishing the heart, calming the nerves, and enhancing gastric function, and is used to treat heart palpitations, neurasthenia, abdominal pain, and stomach problems. The drug is The oral liquid is made from a single herb, Gansong. However, there is only one experiment for its quality control to identify possible terp

Method used

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  • Quality control method for Uighur medicine spikenard strength replenishing preparation
  • Quality control method for Uighur medicine spikenard strength replenishing preparation
  • Quality control method for Uighur medicine spikenard strength replenishing preparation

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Experimental program
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Embodiment 1

[0044] Take Songbuli Oral Liquid as an example to detect the total flavonoids, total flavonoids, total polyphenols and total polysaccharides contained in the Songbuli Oral Liquid as follows.

[0045] (1) Thin-layer chromatography (TLC) qualitative identification of cartoninone and ferulic acid in Songbuli preparations

[0046] The identification of pine new ketone: take 5ml of Songbuli oral liquid, extract with 5ml of petroleum ether, collect the petroleum ether layer, concentrate to 1ml to obtain the test solution, and use the petroleum ether solution of the 1mg / ml standard product of pine new ketone as the reference substance 10 μl each of the test solution and the reference substance were spotted on the same silica gel G plate, and the silica gel G plate used sodium carboxymethyl cellulose as a binder and developed with petroleum ether-ethyl acetate with a volume ratio of 4:1. , dry in the air, spray concentrated sulfuric acid solution with a mass concentration of 5% vanil...

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Abstract

The invention belongs to the field of quality control of Uighur medicine preparations, and particularly discloses a quality control method for a Uighur medicine spikenard strength replenishing preparation. The method comprises the following steps of: (1) qualitatively identifying nardosinone and asafetida in the spikenard strength replenishing preparation by using thin layer chromatography respectively; (2) quantitatively detecting total flavone content, total polyphenol content and total polysaccharide content in the spikenard strength replenishing preparation by using spectrophotography respectively; and (3) quantitatively detecting nardosinone content and asafetida content in the spikenard strength replenishing preparation by using high performance liquid chromatography respectively. According to the quality control method, the nardosinone, the total flavone, the total polyphenol, the total polysaccharide and the asafetida in the spikenard strength replenishing preparation are determined in a combined qualitative and quantitative mode, so that the quality of the finished preparation can be effectively and completely controlled and a reliable foundation is provided for clinical application of medicaments. The method has the characteristics of high sensitivity, high repeatability, high stability, accuracy, reliability and the like.

Description

technical field [0001] The invention belongs to the field of quality control of Uyghur medicine preparations, and in particular relates to a quality control method of Uyghur medicine pine tonic preparations. Background technique [0002] "Drug Standards of the Ministry of Health of the People's Republic of China" (Uyghur medicine sub-volume) announced a Songbuli preparation that has the effects of nourishing the heart, calming the nerves, and enhancing gastric function, and is used to treat heart palpitations, neurasthenia, abdominal pain, and stomach problems. The drug is The oral liquid is made from a single herb, Gansong. However, there is only one experiment for its quality control to identify possible terpenoids based on the color reaction. Quantitative analysis methods and limit requirements, and no qualitative and quantitative analysis methods and limit requirements for active monomer compounds, so the original quality control is not targeted, the method is incomplete...

Claims

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Application Information

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IPC IPC(8): G01N30/90G01N21/31G01N30/02G01N30/36
Inventor 田树革王新宇卢晓丽马庆东周晓英
Owner 新疆天山莲药业有限公司
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