Preparation process of pralidoxime chloride powder injection for injection
A technology for chlorinated phosphonium chloride and preparation process, which is applied in the field of medical drugs and can solve the problems of pH value and related substances rising and content falling.
Active Publication Date: 2012-10-31
JINZHOU AHON PHARM CO LTD
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Problems solved by technology
The present invention aims to solve the problem that the pH value and related substances of the existing pralidoxime injection are increased and the content is decreased after being sterilized at high temperature or stored for a long time
Method used
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The invention discloses a preparation process of pralidoxime chloride powder injection for injection and belongs to the field of medical and pharmaceutical substances. According to research, content of pralidoxime chloride injection which is performed with high-temperature sterilization is reduced, and content of related substances is obviously increased, so that research on preparation of a pralidoxime chloride preparation is conducted, and the process for preparing sterilized powder in a freezing drying method is invented. The preparation obtained through the preparation process is stable in pH value and content of the preparation and the related substances and low in toxicity and the content of the related substances. Safety and effectivity of the pralidoxime chloride are ensured, and product quality can be guaranteed easily.
Description
Technical field [0001] The present invention involves a preparation process for injection and phosphorus phosphorus, and it is specific to the preparation process of a phosphorus phosphorus pink needle for injection, which is the field of medical drugs. Background technique [0002] 1. Pin phosphorus phosphoric injection belongs to the basic drug of the country. The traits are colorless or slightly yellow clear liquids. They have different degrees of resurrection effect on the vitality of choline enzymes suppressed by acute organic phosphorus.Poisoning of organic phosphate pesticides.But poisoning effects such as mima -sulfurized, enemy cachines, dichlorvos, pista, dimefox (Dimefox), propenafox, and Schradan (Schradan) have poor effects;The choline inhibited by the agent has no resurrection. 2. The original execution standard of the fixed injection of chlorine phosphorus is the second volume of the two departments of the Ministry of the People's Republic of China. There is no co...
Claims
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Login to View More IPC IPC(8): A61K9/19A61K31/4425A61P39/02
Inventor 张浩刘新春
Owner JINZHOU AHON PHARM CO LTD