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Anti-aging lipid nanoparticle emulsion for skin and preparation method thereof

A lipid nanoparticle, anti-aging technology, applied in skin care preparations, cosmetic preparations, cosmetics and other directions, can solve the problems of inability to maintain the activity of cosmetics, poor stability, difficult application, etc., to improve the skin anti-aging effect and stability. Good sex, increase the effect of transdermal absorption rate

Active Publication Date: 2014-11-26
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But resveratrol, dimethoxycresyl-4-propyl resorcinol, salicyloyl phytosphingosine are all dissolved in ethanol, insoluble in water and oil, difficult to apply; and resveratrol , dimethoxytolyl-4-propyl resorcinol is very active, but its stability is very poor. For example, the 40% ethanol solution of resveratrol can only be stable for several days under dark conditions, and cannot Long-term active in cosmetics; therefore, although effective, practical use in cosmetics is very difficult

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation method of skin anti-aging lipid nanoparticle emulsion, comprises the following steps:

[0032] 1. Weigh 10.3g of monoglyceride stearate (GLYCERYL STEARATE), 6.1g of hydrogenated soybean oil (HYDROGENATED SOYBEAN OIL), 6.3g of lecithin (LECITHIN), 3.9g of polyglyceryl-4 pentastearate (POLYGLYCERYL- 4 PENTASTEARATE), heated to 78°C, stirred with a propeller stirrer at a speed of 600 rpm for 10 minutes to obtain a uniform liquid oil phase;

[0033] 2. Weigh 3.6g resveratrol, 5.6g dimethoxytolyl-4-propyl resorcinol, 1.2g salicyloyl phytosphingosine, 20.0g ethanol, stir to make the active matter disperse evenly, Then add it to the liquid oil phase obtained in step A, keep it at 78°C, and stir it with a propeller agitator at a speed of 600 rpm for 10 minutes to make it evenly dispersed in the liquid oil phase;

[0034] 3. Weigh 43.0g of water and heat to 80°C;

[0035] 4. Mix the above-mentioned liquid oil phase with water, stir with a propeller agitator at ...

Embodiment 2

[0043] The preparation method of skin anti-aging lipid nanoparticle emulsion, comprises the following steps:

[0044] 1. Weigh 4.3g of monoglyceride stearate (GLYCERYL STEARATE), 1.5g of hydrogenated soybean oil (HYDROGENATED SOYBEAN OIL), 0.7g of hydrogenated palm kernel oil (HYDROGENATED PALM KERNEL OIL), 3.6g of lecithin (LECITHIN), 1.4 g steareth-100 (STEARETH-100), 1.0 g polysorbate-80 (POLYSORBATE 80), heated to 75 ° C, and stirred for 10 minutes with a propeller stirrer at a speed of 600 rpm to obtain a uniform liquid oil phase;

[0045] 2. Weigh 0.06g resveratrol, 0.34g dimethoxytolyl-4-propyl resorcinol, 0.10g salicyloyl phytosphingosine, 5.0g ethanol, stir to make the active matter disperse evenly, Then add it to the liquid oil phase obtained in step A, keep it at 75°C, and stir it with a propeller agitator at a speed of 600 rpm for 10 minutes to make it evenly dispersed in the liquid oil phase;

[0046] 3. Weigh 82.0g of water and heat to 75°C;

[0047] 4. Mix th...

Embodiment 3

[0055] The preparation method of skin anti-aging lipid nanoparticle emulsion, comprises the following steps:

[0056] 1. Weigh 17.0g GLYCERYL STEARATE, 6.2g HYDROGENATED SWEET ALMOND OIL, 3.4g LIMNANTHES ALBA (MEADOWFOAM) SEED OIL), 9.4g lecithin (LECITHIN), 2.8g sucrose stearate (SUCROSE STEARATE), 0.5g glycerol-6 myristate (POLYGLYCERYL-6MYRISTATE), 0.5g polyglyceryl-2 isostearate (POLYGLYCERYL-2 ISOSTEARATE), heating to 85°C, stir with a propeller agitator at a speed of 600 rpm for 10 minutes to obtain a uniform liquid oil phase;

[0057] 2. Weigh 4.0g resveratrol, 2.4g dimethoxytolyl-4-propyl resorcinol, 0.8g salicyloyl phytosphingosine, 15.0g ethanol, stir to make the active matter disperse evenly, Then add it to the liquid oil phase obtained in step A, keep at 85°C, and stir with a propeller agitator at a speed of 600 rpm for 10 minutes to make it evenly dispersed in the liquid oil phase;

[0058] 3. Weigh 38.0g of water and heat to 85°C;

[0059] 4. Mix the above liq...

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Abstract

The invention relates to an anti-aging lipid nanoparticle emulsion for skin and a preparation method of the anti-aging lipid nanoparticle emulsion. The emulsion comprises the following components by mass percentage: 0.5-15.0% of anti-aging mixture for skin, 6.5-26.6% of lipid material, 6.0-13.2% of emulsifying agent, 5.0-25.0% of ethanol and the balance of water, wherein the anti-aging mixture for skin is made up of resveratrol, dimethoxytolyl propylresorcinol and salicyloyl phytosphingosine. The method mainly comprises the steps of preparing a liquid state oil phase and an aqueous phase, and carrying out high pressure homogenization on the liquid state oil phase and the aqueous phase with temperature of 75-85 DEG.C, pressure of 80-150 MPa and stirring speed of 600rpm. The invention has the following advantages: the contents of the loaded resveratrol, dimethoxytolyl propylresorcinol and salicyloyl phytosphingosine are high, the stability of the emulsion is good, the anti-aging effect for skin is remarkable, the transdermal absorption rate of the effective components is high, and the emulsion is conveniently added into a formula of the cosmetics via a cooling distribution.

Description

technical field [0001] The invention relates to the technical field of preparation of lipid nanoparticles, in particular to a skin anti-aging lipid nanoparticle emulsion and a preparation method thereof. Background technique [0002] On the one hand, skin aging is caused by oxygen free radicals attacking the collagen and elastic fibers in the skin, causing collagen denaturation and elastic fiber breakage; on the other hand, with the increase of age, the proliferation of collagen and elastin in the skin slows down, The damaged part cannot be compensated in time; at the same time, with aging, the skin will appear pigmentation, and then develop into age spots; the skin gradually loses its elasticity, and then becomes loose, wrinkled, and full of spots. As the aging society enters, skin anti-aging cosmetics are more and more popular among the public. Skin anti-aging is a comprehensive process. On the one hand, it is necessary to reduce the generation of oxygen free radicals in ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/97A61K8/42A61K8/34A61K8/06A61Q19/08
Inventor 陆海英陈斌
Owner PROYA COSMETICS
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