Chitosan oligosaccharide containing medicine composition with blood fat reducing function

A technology containing chitosan oligosaccharides and compositions, which is applied in the field of medicine to achieve the effect of small side effects

Active Publication Date: 2012-11-21
山东卫康生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these western medicines can lower blood lipid levels, their toxic and side effec

Method used

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  • Chitosan oligosaccharide containing medicine composition with blood fat reducing function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The preparation of embodiment 1 capsule

[0018] (1) Dissolve chitosan in 1%-5% (v / v) acetic acid solution at a concentration of 5% (w / v), add chitosan enzyme equivalent to 5% of chitosan weight, heat up and stir React at 30°C, start ultrafiltration after 60 hours, the part with a molecular weight cut off of 300 passes through the filter membrane, and the molecules with a molecular weight cut off of 6000 return to the reactor to continue to degrade, and the ultrafiltrate passes through the nanofilter, and the part that passes through is water and acetic acid And small molecule sugar, the unpermeable part is concentrated into 50% chitosan oligosaccharide with a polymerization degree of 2-50, then precipitated with 75% ethanol, filtered, and the supernatant is spray-dried to form a pharmaceutical grade with a polymerization degree of 2-50 Oligochitosan; wherein the content of oligochitosan with a degree of polymerization of 4-30 is 67%.

[0019] (2) Heat and reflux the ...

Embodiment 2

[0022] Example 2 The effect test of the combination of chitosan oligosaccharide, ginkgo biloba extract and grape seed extract on obese hyperlipidemia mice

[0023] 4-week-old KM mice, half male and half female, were fed with high-fat feed (the formula of high-fat feed was casein 1kg, L-cysteine ​​15g, maltodextrin 0.75kg, sucrose 0.35kg, cellulose 0.25kg, soybean oil 0.15kg, lard 1.25kg). After 10 weeks of feeding, mice with body weight less than 60 g were eliminated, and then administered in groups. See Table 1 for the method of administration in groups.

[0024] The test substance and dosage of each group of mice in Table 1

[0025]

[0026] Note: chitosan oligosaccharides, ginkgo biloba extract and grape seed extract are all prepared according to the process of Example 1 of the present invention.

[0027] During the administration period, the rats were still fed with high-fat feed, orally administered twice a day at 9:00 and 21:00, respectively, for 8 consecutive wee...

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Abstract

The invention discloses a chitosan oligosaccharide containing medicine composition with a blood fat reducing function, and relates to the technical field of medicines. Active components of the medicine composition include chitosan oligosaccharide, ginkgo biloba extract and grape pip extract, and the weight ratio of the chitosan oligosaccharide to the ginkgo biloba extract to the grape pip extract is 1:0.1-1:1-10. All the active components of the medicine composition are natural products, have fewer side effects, are safe and reliable, and have remarkable blood fat regulating and slimming functions.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition containing chitosan oligosaccharide with the function of lowering blood fat. Background technique [0002] Abnormal fat metabolism or operation makes one or more lipids in plasma higher than normal, which is called hyperlipidemia. Hyperlipidemia is a systemic disease, refers to blood total cholesterol (TC) and / or triglyceride (TG) is too high or high-density lipoprotein cholesterol (HDL-C) is too low, modern medicine is called dyslipidemia . The damage to the body of the disease is insidious, gradual, progressive and systemic. Its direct damage is to accelerate systemic atherosclerosis, because vital organs of the whole body rely on arterial blood supply and oxygen supply. Once the arteries are blocked by atherosclerotic plaques, serious consequences will result. Renal failure caused by arteriosclerosis is closely related to hyperlipidemia. A lar...

Claims

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Application Information

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IPC IPC(8): A61K36/87A61P3/06A61K31/722
Inventor 徐纪文王宗继焦念强
Owner 山东卫康生物医药科技有限公司
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