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Novel delivery assisting gel and preparation method and application of novel delivery assisting gel

A technology of gel and purified water, applied in medical science, surgery, etc., can solve problems such as poor lubrication effect of the composition, danger, unfavorable for babies, etc.

Active Publication Date: 2014-04-02
山西纳德西生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] However, the disadvantage is that, on the one hand, because the puerpera will have physiological fluids such as amniotic fluid and blood to flow out from the birth canal during childbirth, the lubricating effect of the lubricant composition will often be weakened. It is easy to clean, but has a better affinity for natural ingredients with lubricating properties, and will not weaken its lubricating effect with physiological body fluids. Therefore, the lubricating effect of the composition provided by the above technical solution is not good; and on the other hand, the reality The situation is that because the immune level of the mother and fetus is very low during childbirth, the birth canal will be bleeding and an episiotomy is often performed, and the chances of local and systemic infection are very likely to increase during childbirth. Therefore, midwifery lubricants It is very important to have high-efficiency lubricating effect, safety and antibacterial properties, but the use of antibiotic chemicals in midwifery lubricants is often harmful to babies, and even very dangerous

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0117] Embodiment 1, a kind of delivery aid gel contains:

[0118] Chitosan (30-40mPa.S viscosity model) 1g,

[0119] Macrogol-400 10g,

[0120] Hydroxyethyl cellulose (80,000 mPa.S viscosity model) 1g

[0121] Glycerin 10g,

[0122] Sodium chloride 0.45g,

[0123] Appropriate amount of lactic acid or hydrochloric acid, adjust the pH of chitosan gel to 3-6,

[0124] Add purified water to 100g;

[0125] Preparation method: (1) Add chitosan to 30ml of purified water, stir evenly, gradually add appropriate amount of lactic acid or hydrochloric acid to make the reactant form a gel, and make the pH of the gel between 3 and 6, and add sodium chloride Dissolve and stir evenly to obtain the first mixture gel;

[0126] (2) Disperse hydroxyethyl cellulose in 40ml of purified water. After fully swelling, add glycerin and mix well to obtain the second mixture gel;

[0127] (3) Combine the above two mixture gels and polyethylene glycol-400, ...

Embodiment 2

[0128] Embodiment 2, a kind of delivery aid gel contains:

[0129] Chitosan (40mPa.S viscosity model) 1g,

[0130] Macrogol-400 10g,

[0131] Hydroxyethyl cellulose (80,000 mPa.S viscosity model) 1g

[0132] Glycerin or Propylene Glycol 10g,

[0133] Sodium chloride 0.45g,

[0134] Appropriate amount of lactic acid or hydrochloric acid, adjust the pH of chitosan gel to 3-6,

[0135] 0.5g olive oil,

[0136] Add purified water to 100g;

[0137] Preparation method: (1) Add chitosan to 30ml of purified water, stir evenly, gradually add appropriate amount of lactic acid or hydrochloric acid to make the reactant form a gel, and make the pH of the gel between 3 and 6, and add sodium chloride Dissolve, stir well, and mix well with olive oil, homogenize to get the first mixture gel;

[0138] (2) Disperse hydroxyethyl cellulose in 40ml of purified water. After fully swelling, add glycerin or propylene glycol and mix well to obtain...

Embodiment 3

[0140] Embodiment 3, a kind of delivery aid gel, contains:

[0141] Chitosan 0.8g,

[0142] Macrogol-1000 or Macrogol-400 5g

[0143] Hydroxyethyl cellulose 1~3g (depending on different viscosity models),

[0144] Glycerin or Propylene Glycol 12g,

[0145] Sodium chloride 0.44g,

[0146] Appropriate amount of lactic acid or hydrochloric acid, adjust the pH of chitosan gel to 3-6,

[0147] Add purified water to 100g;

[0148] Preparation method: (1) Add chitosan to 25ml of purified water, stir evenly, gradually add appropriate amount of lactic acid or hydrochloric acid to make the reactant form a gel, and make the pH of the gel between 3 and 6, and add sodium chloride Dissolve and stir evenly to obtain the first mixture gel;

[0149] (2) Disperse hydroxyethyl cellulose in 45ml of purified water. After fully swelling, add glycerin or propylene glycol and mix well to obtain the second mixture gel;

[0150] (3) Combine the above two mixtur...

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PUM

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Abstract

Disclosed is a composition with a lubricating effect. The composition comprises chitosan, polyethylene glycol, a water-soluble thickener, a humectant and optional water. The composition is used for preparing a medical product used as a lubricant for vaginal delivery, has good safety and antibacterial effects, and can effectively assist delivery, so that delivery is carried out easily, and a delivery birth process and delivery time are shortened.

Description

technical field [0001] The invention relates to the field of medical products, and relates to a new delivery aid gel, which is a composition with good lubricating and antibacterial effects, and is especially used for puerpera during childbirth. The invention also relates to its preparation method and application. Background technique [0002] Maternal childbirth is a complicated process. Obstetrics and gynecology studies have proved that childbirth is determined by three factors: the delivery product (fetus, amniotic membrane, placenta), birth canal and parturition. Obstetrics and gynecology studies have shown that the force that promotes delivery is uterine contractions and Gravity, and the force that inhibits delivery is the resistance of the cervix and the birth canal. The delivery of a human baby is divided into three stages: the opening period, the delivery period and the postpartum period. Normal labor lasts an average of 12 hours in primiparous women and 8 hours in mu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61L31/04A61L31/14
Inventor 张耿元赵海静白东跃
Owner 山西纳德西生物科技有限公司
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