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Method for preparing lutein crystal from marigold flowers

A technology of marigold flowers and lutein, applied in the direction of organic chemistry, can solve the problems of high cost, low extraction yield, complicated process, etc., and achieve the effect of improving production efficiency, increasing extraction rate, and high yield

Active Publication Date: 2014-05-21
CHENGUANG BIOTECH GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method has the characteristics of low extraction yield, long saponification reaction time, complex process, high cost, and difficult recovery of solvents.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: The process steps of the method for preparing crystalline lutein from marigold flower particles are as follows.

[0016] Weigh 50g of marigold granules with a total carotenoid content of 1.83wt%, add 150g of 40wt% potassium hydroxide aqueous solution to it, keep stirring at 80°C, and saponify for 5 hours. After the saponification was completed, 300 g of 2 wt % sodium chloride aqueous solution was added thereto, heated to 80° C., stirred evenly, and then filtered to obtain a filter cake. Add n-hexane solvent to the filter cake to extract fat-soluble components therein at 40°C, add 5ml of n-hexane solvent per gram of filter cake, and filter to obtain a fat-free filter cake. Add tetrahydrofuran solvent to the degreasing filter cake, extract twice at 50°C, add 5ml of tetrahydrofuran solvent per gram of degreasing filter cake to obtain a tetrahydrofuran extract containing lutein; add 0.75 times its volume to the extract Deionized water, stirred evenly at 35°C, al...

Embodiment 2

[0017] Example 2: The process steps of the method for preparing crystalline lutein from marigold flower particles are as follows.

[0018] Weigh 50g of marigold granules with a total carotenoid content of 1.94wt%, add 300g of 45wt% potassium hydroxide aqueous solution to it, keep stirring at 85°C, and saponify for 4.5 hours. After the saponification was completed, 350 g of 5 wt % sodium chloride solution was added thereto, heated to 80° C., stirred evenly, and then filtered to obtain a filter cake. Add n-pentane solvent to the filter cake to extract fat-soluble components therein at 35°C, add 4ml of n-pentane solvent per gram of filter cake, and filter to obtain a fat-free filter cake. The tetrahydrofuran solvent added to the fat-free filter cake was extracted twice at 55°C, and 4ml of tetrahydrofuran solvent was added to each gram of fat-free filter cake to obtain a tetrahydrofuran extract containing lutein; 1 times its volume was added to the extract deionized water, stirre...

Embodiment 3

[0019] Example 3: The process steps of the method for preparing crystalline lutein from marigold flower particles are as follows.

[0020] Weigh 100g of marigold granules with a total carotenoid content of 1.90wt%, add 800g, 50wt% potassium hydroxide aqueous solution to it, keep stirring at 75°C, and saponify for 6 hours. After the saponification was completed, 300 g of 4 wt % sodium chloride aqueous solution was added thereto, heated to 85° C., stirred evenly, and then filtered to obtain a filter cake. Add n-heptane solvent to the filter cake to extract fat-soluble components therein at 30°C, add 6ml of n-hexane solvent per gram of filter cake, and filter to obtain a fat-free filter cake. Add tetrahydrofuran solvent to the degreasing filter cake, extract at 60°C, add 6ml of tetrahydrofuran solvent per gram of degreasing filter cake to obtain tetrahydrofuran extract containing lutein; add 0.5 times its volume to the extract water, stirred evenly at 55°C and allowed to stand f...

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PUM

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Abstract

The invention discloses a method for preparing a lutein crystal from marigold flowers, and the method comprises the following steps of: adding an alkali aqueous solution to marigold flower particles to saponify; then adding saline water, uniformly stirring and filtering to obtain a filter cake; extracting the filter cake by using an alkane solvent, and filtering to obtain a degreasing filter cake; extracting the degreasing filter cake by using tetrahydrofuran to obtain extract liquor; and washing the extract liquor with water, then recrystallizing, carrying out fractional crystallization, and drying to obtain the lutein crystal. According to the method, as the marigold flower particles are directly saponified by using the alkali aqueous solution, the production efficiency is beneficially improved; after the marigold flower particles are saponified, the generated saponin substances are removed by using the saline water, the phenomenon of wasting a large amount of lutein crystals in the traditional process when the saponin substances are removed is avoided; and due to the characteristics of small dissolvability of the lutein crystal in the alkane solvent, a lot of target substances are avoided from being taken away when the lutein crystal is purified in the conventional process, so that the extracting rate is effectively improved.

Description

technical field [0001] The invention relates to a method for preparing lutein, in particular to a method for preparing crystal lutein from marigold flower granules. Background technique [0002] Lutein belongs to the tetraterpenoids of carotenoids, which widely exist in the flowers, leaves, fruits and some algae organisms of plants, especially in the petals of marigolds, which exist in the form of leaves in plants. Lutein esters are generally obtained by alkaline saponification in the industry. Lutein is an orange-red to orange-yellow powder with a weak licorice smell. It is easily soluble in organic solvents such as tetrahydrofuran, chloroform, and cyclohexanone, and its solubility in n-hexane is very small. In recent years, the biological function of lutein has attracted more and more attention. Lutein has a strong antioxidant effect and can remove harmful substances "free radicals" produced in the process of physiological metabolism in the human body. Such "free radical...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C403/24
Inventor 苏学辉安晓东宋建岭连运河
Owner CHENGUANG BIOTECH GRP CO LTD
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