Antagonism of human formyl peptide receptor for treatment of disease

Abstract

The present invention is directed to modulators of eosinophilic and neutrophilic function and the use of such modulators for treatment of eosinophil-associated and neutrophil-associated diseases.

Description

Background technique [0001] Eosinophils and neutrophils are blood cells that play an important role in the immune response. Eosinophils are immune cells that, in addition to their role in fighting parasitic infections, have been implicated in a variety of immune and allergic diseases. They form in the bone marrow and migrate into the blood. Unstimulated circulating eosinophils remain in the bloodstream for 8-12 hours. There are a variety of factors that regulate eosinophil differentiation, including IL-3, IL-5, and GM-CSF. In particular, animal models were the first to show that IL-5 plays a dominant role in the diffusion and migration of eosinophils from the bone marrow to the bloodstream and to the lungs. [0002] Asthma is a highly prevalent allergic disease with complex and poorly understood etiology. Although a variety of animal (eg, mouse) models exist, no single animal model accurately captures all of the physiological and pathological features of the disease. None...

AI Technical Summary

Problems solved by technology

Short-term high-dose ibuprofen or other anti-inflammatory agents can be useful in addressing the deep and protracted inflammation characteristic of CF lungs, but toxicity to the liver and other organs, especially in pediatric patients, prevents their long-term use

Similarly, corticosteroid therapies have some utility, but side effects prevent their widespread or common use

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