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Powder composition containing glucose and preparation method thereof

A technology of composition and glucose, applied in the field of medicine, can solve the problems of clumping into balls, clumping into agglomerates, affecting the packaging of medicines, etc.

Active Publication Date: 2014-07-09
西安安健药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, in the process of powder preparation and storage of finished products, various problems may be encountered, such as agglomeration and ball formation during the preparation process, which will affect drug packaging; agglomeration during storage may affect the dissolution of the drug during use

Method used

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  • Powder composition containing glucose and preparation method thereof
  • Powder composition containing glucose and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] prescription: 1 part by weight of potassium chloride, 1.73 parts by weight of sodium chloride, 1.93 parts by weight of sodium citrate, and 9 parts by weight of glucose.

[0083] Preparation:

[0084] (1) Weigh each material of corresponding amount, mix evenly;

[0085] (2) pulverize on a suitable pulverizer, monitor the particle size change and appearance uniformity of the material at any time during the pulverization process (in the present invention, the "particle size change" of the above-mentioned monitoring material at any time can be carried out according to the above-mentioned method A; "Appearance uniformity" can refer to the [appearance uniformity] inspection method under the powder item of the second appendix of the Chinese Pharmacopoeia in 2012 edition, so as to ensure the uniformity of potassium chloride, sodium chloride and sodium citrate in the material);

[0086] (3) When the particle size of the material is detected by method A, and when about 70% o...

Embodiment 2

[0088] prescription: 1 part by weight of potassium chloride, 2.33 parts by weight of sodium chloride, 1.93 parts by weight of sodium citrate, and 13.3 parts by weight of glucose.

[0089] Preparation: Carried out with reference to the method of Example 1 to obtain the composition of the present invention (referred to as R2).

Embodiment 3

[0091] prescription: 1 part by weight of potassium chloride, 2.4 parts by weight of sodium chloride, 1.6 parts by weight of sodium citrate, and 14 parts by weight of glucose.

[0092] Preparation: Carry out with reference to the method of embodiment 1, obtain composition of the present invention.

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Abstract

The invention relates to a powder composition containing glucose and a preparation method thereof. Specifically, the powder composition comprises glucose, halogen salt of potassium, halogen salt of sodium and the like. The powder composition has excellent medical performance.

Description

technical field [0001] The invention belongs to the technical field of medicines and relates to a powdery composition which contains glucose and salts of Na ions and K ions. Background technique [0002] Oral supplementation of salt in body fluids is the drug recommended by the World Health Organization for the treatment of acute diarrhea dehydration. These drugs have reasonable prescriptions, are cheap and easy to obtain, are convenient and efficient, and their speed of correcting dehydration is better than that of intravenous infusion. It is used to treat mild and moderate dehydration caused by indigestion and autumn diarrhea in children. [0003] It has been found that an effective formulation for salt replacement in body fluids contains dextrose, sodium chloride, potassium chloride, and sodium citrate as active ingredients, and the formulation can be directly Prepared into preparations, such as granules, powders and the like. In terms of the controllability of the phar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/14A61P3/02A61K31/194A61K31/7004
Inventor 王伟
Owner 西安安健药业有限公司