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Adhesion-preventing material

An anti-adhesion, carboxymethyl cellulose technology, applied in the directions of drug combination, surgery, coating, etc., can solve the problems of unpredictable anti-adhesion effect, complicated sealing operation, insufficient effect, etc., and achieve excellent anti-adhesion effect. Effect

Inactive Publication Date: 2013-01-02
HOGY MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, as a commercially available anti-adhesion material, Seprafilm (Seprafilm) (Genzyme Japan K.K. (Genzyme Japan) is known, which contains sodium hyaluronate and carboxymethylcellulose in a ratio (weight ratio) of 2:1. Translucent film-like anti-adhesion material), Interceed (Interceed) (Johnson & Johnson K.K. (Jionson Ender Johnson), regenerated oxidized cellulose net), but anti-adhesion materials with more excellent anti-adhesion effects are expected
For example, in the above-mentioned Patent Document 3, it is described that although the effect of an anti-blocking material using an aqueous solution of carboxymethylcellulose sodium was confirmed, a sufficient effect was not obtained.
In addition, Seprafilm (セプララフィルム) sticks to each other when it gets wet, sticks to your hand if you touch it with wet hands and is difficult to reattach, and depending on the storage conditions, it will crack if it dries too much The operation of sealing and sealing is complicated, and a sufficient anti-adhesion effect cannot be expected from this aspect.

Method used

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Examples

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Effect test

preparation example Construction

[0054] In the preparation method of the present invention, acid treatment is carried out to the structure formed by alkali metal CMC (preferably Na-type CMC) while maintaining its structure, before the alkali metal CMC is completely converted into acid CMC, such as acid treatment The above-mentioned acid treatment is terminated before reaching the central part or inner part of the above-mentioned structure (hereinafter referred to as the first production method). Or, carry out alkali treatment to the structure body that acid type CMC forms under the state that maintains its structure, before acid type CMC is completely converted into alkali metal type CMC (preferably Na type CMC), for example alkali treatment reaches the center of above-mentioned structure Or finish the above alkali treatment before the inner part (hereinafter referred to as the second production method). The structure formed by the alkali metal type CMC is easy to form an aqueous solution by adding water beca...

Embodiment 1

[0097] (1) Preparation of non-woven anti-adhesion material

[0098] 0.17g of rayon nonwoven fabric (size 10cm×10cm, unit area weight 17g / m 2 , thickness 0.08mm) into the reaction vessel, add 1L of sodium hydroxide-containing ethanol aqueous solution (4.2mol / L sodium hydroxide, 9.3mol / L ethanol), and incubate at room temperature for 17 hours. Further, 615 mL of monochloroacetic acid-containing ethanol aqueous solution (4.9 mol / L monochloroacetic acid, 10.3 mol / L ethanol) was added, and cultured at 50° C. for 4 hours. Wash with 70% aqueous methanol and 80% aqueous methanol in sequence, and then neutralize to pH 6.0~8.0 with aqueous methanol containing hydrochloric acid (1.2mol / L hydrochloric acid, 90% methanol).

[0099] Then, it was washed with 80% methanol aqueous solution and 100% methanol in this order, and then dried to obtain a sheet (1). Most of the CMCs constituting this sheet are Na-type CMCs. In addition, at this time, the degree of etherification was 0.83, and the ...

Embodiment 2

[0116] (1) Preparation of film-like anti-adhesion material

[0117] The sheet (1) composed of Na-type CMC (etherification degree: 0.83, molecular weight: 160,000 Da) obtained as an intermediate product in Example 1 (1) was dissolved in water to make the concentration 50 mg / mL, and prepared Na-type CMC aqueous solution. Of these, 5 mL was added to a slide glass (76 mm×26 mm), and left at room temperature for 2 days and nights to dry. The obtained membranous substance was peeled off from the glass slide, cut into slices (2 cm×1 cm), and 10 slices were put into 50 mL plastic tubes.

[0118] Add 30 mL of methanolic aqueous solution containing hydrochloric acid (1.2 mol / L hydrochloric acid, 90% methanol) to each tube, and incubate at room temperature for 0 hour (ie untreated) and 2 hours. After culturing, wash with 80% methanol aqueous solution and 100% methanol in sequence, and then dry to obtain the anti-adhesion material sample of the present invention.

[0119] (2) Evaluatio...

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Abstract

Disclosed are: a process for producing a novel carboxymethyl cellulose (CMC) structure which is useful as a medical material, particularly an adhesion-preventing material; and a CMC structure which has excellent biocompatibility and bioabsorbability and of which the period required for developing the function thereof and the period required for the dissolution thereof can be controlled, or a CMC structure which can exhibit both an adhesion-preventing effect and a wound-healing effect at the same time. The structure is substantially composed of carboxymethyl cellulose components, wherein an oxidized carboxymethyl cellulose and an alkali metal type carboxymethyl cellulose are contained in a mixed state. The process is characterized in that the outside of a structure composed of an alkali metal type (or acid type) carboxymethyl cellulose is treated with an acid (or an alkali) and the acid treatment (or the alkali treatment) is completed before the alkali metal type (or acid type) carboxymethyl cellulose is entirely converted into an acid type (or alkali metal type) carboxymethyl cellulose.

Description

technical field [0001] The invention relates to an anti-adhesion material for preventing postoperative organ adhesion. [0002] In addition, the present invention relates to a carboxymethylcellulose (CMC) structure and a preparation method thereof. The CMC structure of the present invention can be used, for example, as a medical material, more specifically, it can be used for articles that require the property of being absorbed / excreted after maintaining a shape for a certain period of time in a living body, such as anti-adhesion materials, sheet-like fibrin adhesives Base material for DDS, base material for DDS, absorbable suture reinforcement, artificial dura mater, bone bonding material, absorbable suture, etc. Background technique [0003] In clinical fields such as cardiac surgery, orthopedic surgery, neurosurgery, abdominal surgery, obstetrics and gynecology, after various surgical procedures or due to trauma, the adhesion of the affected part to the surrounding biolo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/00
CPCA61L31/148A61L31/048A61P41/00C08B11/12C08B11/20C08J5/18C08J2301/28C08L1/286C08L2205/025C08L2205/16C08L1/28A61L31/00A61L31/10
Inventor 徐吉夫青岛元法井上利树长谷川清孝
Owner HOGY MEDICAL CO LTD
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