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Anti-cancer medicament silicon plastid microcapsule and preparation method thereof

An anti-cancer drug and microcapsule technology, applied in the field of biomedical materials, can solve the problems of uniform particle size, affecting practical application, wide range of siliceous particle size distribution, etc., achieving good stability, uniform and controllable particle size, The effect of more controllable size

Inactive Publication Date: 2013-01-30
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a drug carrier, siliceous bodies have solved the various deficiencies of liposomes well, but there is a problem at the same time, that is, the particle size distribution of siliceous bodies is wide, and the particle size cannot be made uniform by conventional preparation methods. affect their future practical application

Method used

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  • Anti-cancer medicament silicon plastid microcapsule and preparation method thereof
  • Anti-cancer medicament silicon plastid microcapsule and preparation method thereof
  • Anti-cancer medicament silicon plastid microcapsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Prepare 0.025M Na respectively 2 CO 3 、 Ca(NO 3 ) 2 100mL each solution Ca(NO 3 ) 2 Add 400mg polystyrene sodium sulfonate (PSS) to the solution, after it is completely dissolved, quickly add Na 2 CO 3 Solution, stirred at 600 rpm for 15s, left to stand for 20min, centrifuged and washed three times to obtain calcium carbonate particles with a particle size of 5 microns, the laser confocal photo is shown in figure 2 .

[0036] (2) Precisely weigh 10 mg of organic-inorganic composite lipid 1 and dissolve it in 2 mL of chloroform, remove the chloroform by rotary evaporation, and form a transparent lipid film at the bottom of the eggplant-shaped bottle. 4mg / mL uniform particle size and positively charged CaCO 3 Add 5 mL of the microsphere solution into the lipid film, incubate in a water bath at 45°C for 30 min, and then sonicate in a water bath for 5 min. After standing at room temperature for 12 hours, add 0.2M EDTA solution to react for a period of ...

Embodiment 2

[0039] (1) Same as Step 1 of Example 1;

[0040] (2) Same as step 2 of embodiment 1;

[0041] (3) Same as Step 3 of Example 1, the siliceous microcapsules loaded with doxorubicin hydrochloride are released in the phosphate buffer solution of pH=7.4 and pH=5.0, and the drug release rate is detected, see Figure 5 . This experimental group can show that doxorubicin hydrochloride encapsulated in siliceous microcapsules can play a slow-release effect on the drug, and has a good slow-release effect under neutral or acidic conditions.

Embodiment 3

[0043] (1) Same as Step 1 of Example 1;

[0044] (2) Same as Step 2 of Example 1, except that the lipid used is organic-inorganic composite lipid 2.

[0045] (3) Same as Step 3 of Example 1, the encapsulation efficiency of doxorubicin hydrochloride was 84.4%. It shows that the siliceous microcapsules prepared with organic-inorganic composite lipid 2 have the ability to encapsulate hydrophilic drugs, and the encapsulation efficiency is very high.

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Abstract

The invention discloses an anti-cancer medicament silicon plastid microcapsule and a preparation method thereof. Calcium carbonate microspheres are taken as a template, an organic-inorganic compound lipid is assembled on the surfaces of colloid microspheres through a sol-gel and self-assembling method, and a fat-soluble anti-cancer medicament can be loaded onto a lipoid bilayer simultaneously. Calcium carbonate template microspheres are removed through a chemical method to obtain a monodisperse silicon plastid microcapsule with uniform and controllable particle diameter has stable property. The silicon plastid microcapsule and a water-soluble anti-cancer medicament are incubated together, so that the water-soluble medicament is embedded into a microcapsule. The organic-inorganic compound lipid for preparing the microcapsule is nontoxic and has high biocompatibility. The preparation method provided by the invention has the advantages of simple process, mild operating conditions, high repeatability, good delayed release effect, suitability for embedding and controlled release of fat-soluble anti-cancer medicaments and water-soluble anti-cancer medicaments, and good application prospect.

Description

[0001] technical field [0002] The invention relates to the field of biomedical materials, in particular to an anticancer drug siliceous microcapsule and a preparation method thereof. Background technique [0003] Malignant tumors are one of the diseases that seriously endanger human health, and chemotherapy is currently an indispensable treatment. However, the current chemotherapeutic drugs not only kill tumor cells but also kill normal cells after entering the human body in a free form, causing serious toxic and side effects. Clinically, the side effects of anticancer drugs are mainly manifested in: inhibition of bone marrow hematopoietic function, reduction of platelets and leukocytes, and gastrointestinal reactions. Some drugs have obvious toxicity to the heart and liver. These toxic effects increase the suffering of patients during chemotherapy and largely limit the clinical application of anticancer drugs. Liposomes have been paid more and more attention as carriers...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/24A61P35/00
Inventor 曹众张春阳蒋庆
Owner SUN YAT SEN UNIV
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