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Antibody composition

A technology for antibody group and antibody preparation, which is applied in the direction of antibodies, drug combinations, anti-inflammatory agents, etc.

Inactive Publication Date: 2013-02-27
CSL BEHRING AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0015] However, while many antibody products are currently used therapeutically, there remains a need to provide alternative and / or improved antibody preparations with more beneficial effectiveness in clinical applications

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  • Antibody composition
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Embodiment Construction

[0041] The present invention relates to methods of producing antibody populations, and the resulting antibody populations having enhanced immunomodulatory activity. The method is based on fractionation by affinity chromatography on a Western elderberry (Sambucus nigra) agglutinin (SNA) affinity matrix or its equivalent. The antibody population has enhanced immunomodulatory activity compared to the antibody preparation prior to fractionation or even compared to the total fraction (+SNA) of antibodies eluted from the affinity matrix. Immunomodulatory activity can be determined using, for example, in vitro assays for measuring anti-inflammatory activity. This assay is well known to those skilled in the art. Preferably, the assay measures the inhibition of the effect of an inflammatory stimulus on blood cells or cell lines, such as peripheral blood mononuclear cells (PBMC) or cell lines stimulated by phytohemagglutinin, LPS; interferon-gamma, TLR agonists or other agents Such as...

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Abstract

The invention relates to populations of antibodies obtainable by fractionation of plasma immunoglobulins, in particular plasma IgG, by affinity chromatography on a Sambucus nigra affinity column, and uses thereof.

Description

【Technical field】 [0001] The present invention relates to the antibody group obtainable by fractionation of plasma immunoglobulin, especially plasma IgG, by affinity chromatography on Sambucus nigra affinity column, and its use. 【Background technique】 [0002] Immunoglobulins, also known as antibodies, are the main secretory products of the immune system. They are generally formed from basic structural units each having 2 heavy and 2 light chains to form a monomer with one such unit, a dimer with 2 units, a pentamer with 5 units, or a monomer with 6 unit hexamers. Antibodies play a prominent role in innate immunity. In a natural immune response against a pathogen, a complex is formed between the pathogen and the antibody. These immune complexes activate a wide range of effector functions, thereby leading to the killing, removal and destruction of pathogens. Antibodies can also react with the body's own antigens, which can lead to autoimmune diseases, and contribute to ch...

Claims

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Application Information

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IPC IPC(8): C07K16/00A61K39/395A61P37/00C07K16/06
CPCC07K2316/52C07K1/22C07K16/00A61K2039/505C07K2317/41C07K2317/55C07K16/065A61P17/00A61P19/02A61P21/00A61P25/00A61P25/16A61P25/28A61P29/00A61P37/00A61P37/02A61P37/06A61P7/00
Inventor F·卡瑟曼S·梅斯舍尔
Owner CSL BEHRING AG