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Pharmaceutical composition containing sophora alopecuroide oil and preparation method thereof

The technology of Sophora sophora and its composition, which is applied in the field of traditional Chinese medicine compound preparations, can solve the problems of large side effects and poor effect, and achieve the effects of less side effects, good anti-inflammatory effect, and fast antipruritic and swelling removal

Inactive Publication Date: 2013-03-13
HEFEI YIFAN PHARMA MANAGEMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The existing drugs on the market for the treatment of various common skin diseases all have problems such as poor effect and large side effects

Method used

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  • Pharmaceutical composition containing sophora alopecuroide oil and preparation method thereof
  • Pharmaceutical composition containing sophora alopecuroide oil and preparation method thereof
  • Pharmaceutical composition containing sophora alopecuroide oil and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Recipe: Sophora 2800g; matrine 2g; polysorbate 80 60ml; ethanol 100ml osmanthus essence 25ml; water to 1000ml.

[0022] Preparation method: Take the dried bitter beans and put them in a dry distillation kettle, and dry them at high temperature. Temperature to 180 degrees, keep warm for 1 hour, collect about 400ml of retorted oil. Add 2g of matrine and 8060ml of polysorbate, stir evenly, add 25ml of sweet-scented osmanthus essence, 100ml of ethanol, and add water to adjust to 1000ml. Grind through a colloid mill to obtain the product.

Embodiment 2

[0024] Recipe: Sophora 3000g; matrine 1g; polysorbate 80 50ml; ethanol 200ml; sweet-scented osmanthus essence 30ml; add water to 1000ml.

[0025] Preparation method: Take the dried bitter beans and put them in a dry distillation kettle, and dry them at high temperature. Collect about 480ml of dry distilled oil. Add 1g of matrine, 50ml of polysorbate 80, stir evenly, add 30ml of sweet-scented osmanthus essence, 200ml of ethanol, add water to adjust to 1000ml. Grind through a colloid mill to obtain the product.

Embodiment 3

[0027] Recipe: Sophora 3500g, matrine 1.5g, ethanol 100ml, polysorbate-8070ml, sweet-scented osmanthus essence 20ml, add water to 1000ml.

[0028] Preparation method: Take the dried bitter beans and put them in a dry distillation kettle, and dry them at high temperature. Collect about 560ml of dry distilled oil. Add 1.5g of matrine and 8070ml of polysorbate, stir evenly, add 20ml of sweet-scented osmanthus essence, 100ml of ethanol, add water to adjust to 1000ml. Grind through a colloid mill to obtain the product.

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Abstract

The invention relates to a pharmaceutical composition containing sophora alopecuroide oil and a preparation method thereof. The pharmaceutical composition provided by the invention is prepared from sophora alopecuroide and sophocarpidine which are used as raw materials. The preparation method of the pharmaceutical composition comprises the following steps of: performing destructive distillation on the sophora alopecuroide to obtain destructive distillation oil; mixing the sophocarpidine with the destructive distillation oil; adding polysorbate-80 into the mixture, stirring evenly, and then adding osmanthus flower fragrance, ethanol and a proper amount of water into the mixture, and then grinding the mixture through a colloid mill. The sophora-alopecuroide pharmaceutical composition provided by the invention has certain curative effects of detumescence, proliferation inhibition and the like on acute eczema, and is superior to the conventional sophora alopecuroide oil linimentum in anti-pruritus effect; the sophora-alopecuroide pharmaceutical composition also has certain curative effects of detumescence, proliferation inhibition and the like on chronic eczema; and besides, the sophora-alopecuroide pharmaceutical composition has certain antiphlogosis and skin tissue repair effects on dermatitis induced by the chronic eczema, and is superior to the sophora alopecuroide oil linimentum in curative effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound preparation, in particular to a traditional Chinese medicine liniment for skin external use and a preparation method thereof. Background technique [0002] The existing medicines for treating various common skin diseases in the market all have problems such as poor effect and large side effects. Bitter bean oil liniment is refined from Xinjiang's unique Chinese herbal medicine Buya (bitter bean) as a raw material. There are records of bitter beans treating various skin diseases. Modern medicine has proved that the dried seeds of natural bitter beans, the dry distillation oil obtained after dry distillation, contains more than 10 kinds of alkaloids, which have anti-inflammatory, anti-cancer and immunosuppressive effects. Bitter bean oil liniment has positive curative effect on a variety of skin diseases mainly caused by epidermal hyperplasia, and has few side effects. [0003] Liu Jun a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61P17/00A61P17/04A61P29/00A61K31/4375
Inventor 程先锋
Owner HEFEI YIFAN PHARMA MANAGEMENT
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