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Medicine composition capable of clearing heat and removing toxicity and preparation method of stock solution thereof

A heat-clearing, detoxifying and composition technology, applied in the field of pharmaceutical composition and its preparation, can solve the problems that the process and quality standards need to be improved and improved, there is no clear quality control index, and the components are complex, so as to achieve the controllable quality and process, therapeutic Clear symptoms and effective, low cytotoxic effect

Active Publication Date: 2013-03-13
HEBEI SHINEWAY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

One of the main reasons is that Qingkailing injection is a compound preparation with many medicinal flavors and complex ingredients. Among them, animal protein extracted from buffalo horn may be one of the causes of allergies. Chlorogenic acid contained in honeysuckle is also harmful to humans. Sensitization
On the other hand, honeysuckle, gardenia and isatis root have many chemical components, and they are still purified by water extraction and alcohol precipitation. There is no clear quality control index, and the effective components need to be further clarified, and the process and quality standards need to be improved and improved

Method used

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  • Medicine composition capable of clearing heat and removing toxicity and preparation method of stock solution thereof
  • Medicine composition capable of clearing heat and removing toxicity and preparation method of stock solution thereof
  • Medicine composition capable of clearing heat and removing toxicity and preparation method of stock solution thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The injection preparation of medicine of the present invention

[0041] (1) Weigh 10g of cholic acid, 12g of hyodeoxycholic acid, 200g of honeysuckle, 90g of gardenia and 600g of Radix Radix, set aside;

[0042] (2) Add water to decoct gardenia twice, add 6 times the amount of water for the first time, boil for 1 hour; add 4 times the amount of water for the second time, boil for 0.5 hours, filter, and combine the filtrates. The filtrate was subjected to D101 macroporous resin column chromatography, and eluted with 7 times the column volume of water to remove impurities, then eluted with 7 times the column volume of 30% ethanol solution, collected the eluate, concentrated, and dried to obtain Gardenia extract, spare;

[0043] (3) Crush Radix isatidis and extract twice at 50°C for 3 hours each time. Add 60 times the amount of water for the first time, let stand for 3 hours, release the supernatant, add 40 times the amount of water for the second time, let stand for 3 h...

Embodiment 2

[0050] The preparation of the injection of medicine of the present invention

[0051] (1) Weigh cholic acid 15g, hyodeoxycholic acid 16g, honeysuckle 250g, gardenia 120g and Radix Radix 900g, set aside;

[0052] (2) decoct gardenia jasmine 2 times, add 6 times the amount of water for the first time, boil for 1 hour, add 4 times the amount of water for the second time, boil for 0.5 hours, filter, combine the filtrate, and pass through SP826 macroporous resin For column chromatography, first use 7 times the volume of the column to elute with water to remove impurities, then use 7 times the volume of the column to elute with 30% ethanol solution, collect the eluate, concentrate, and dry to obtain the Gardenia jasmine extract for subsequent use;

[0053] (3) Crush Radix isatidis, extract twice at 40°C for 3 hours each time, add 60 times the amount of water for the first time, let it stand, release the supernatant, add 40 times the amount of water for the second time, and filter ,...

Embodiment 3

[0060] The preparation of the injection of medicine of the present invention

[0061] (1) Weigh 12g of cholic acid, 14g of hyodeoxycholic acid, 200g of honeysuckle, 100g of gardenia and 800g of Radix Radix, set aside;

[0062] (2) Add water to decoct gardenia twice, add 6 times the amount of water for the first time, boil for 1 hour, add 4 times the amount of water for the second time, boil for 0.5 hours, filter, combine the filtrate, and pass through HPD300 macroporous resin For column chromatography, first use 7 times the volume of the column to elute with water to remove impurities, then use 7 times the volume of the column to elute with 30% ethanol solution, collect the eluate, concentrate, and dry to obtain the Gardenia jasmine extract for subsequent use;

[0063] (3) Crush Radix isatidis, extract twice at a temperature of 50°C, 3 hours each time, add 60 times the amount of water for the first time, let it stand, release the supernatant, add 40 times the amount of water f...

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Abstract

The invention discloses a medicine composition capable of clearing heat and removing toxicity, and a preparation method of a stock solution of the medicine composition. The medicine composition is prepared by the following components by a certain weight ratio: cholic acid, honeysuckle, gardenia jasminoides ellis and isatis root; and the medicine composition can be prepared into any forms, and injection preparation is preferable. Compared with conventional Qingkailing compound injection, the medicine composition disclosed by the invention has the characteristics of being remarkable in treatment effect and higher in safety.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a heat-clearing and detoxifying medicine and a preparation method of the stock solution thereof. Background technique [0002] Qingkailing Injection was improved from Angongniuhuang Pills in Plague Tiaobian written by Wu Jutong, a blastologist in the Qing Dynasty. It is made of several herbs such as ox horn, mother of pearl and baicalin. It has the effects of clearing away heat and detoxification, resolving phlegm and dredging collaterals, refreshing the mind and resuscitating the mind. It is mainly used in the treatment of febrile disease, coma, stroke hemiplegia, confusion, acute and chronic hepatitis, hepatitis B, upper respiratory tract infection, pneumonia, high fever and cerebrovascular disease. Wait. Satisfactory results have been achieved in the treatment of upper respiratory tract infections, various fevers and acute diseases. [0003] I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61P1/16A61P31/14A61P31/20A61P11/00A61P29/00A61K31/575
Inventor 刘军锋李东张自然郭沛鑫姜海
Owner HEBEI SHINEWAY PHARMA
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