Nano yarn reinforcement electrostatic spinning fiber texture engineering scaffold and method for producing same

Abstract

The invention relates to a nano yarn reinforcement electrostatic spinning fiber texture engineering scaffold and a method for producing the same. The method comprises the processes of building a production device, preparing poly-L-lactic acid / hexafluoroisopropanol electrostatic spinning solution, connecting with high pressure to carry out electrostatic spinning, combining nano fibers to form yarns, collecting nano yarns and nano fibers and the like. The texture engineering scaffold has good tensile mechanical property and is beneficial to keeping the integral structure of the scaffold during the material processing and texture regenerating processes; and the scaffold has large pores to facilitate cells to move into the texture. In addition, the scaffold also has the characteristics of simplicity in producing method and convenience in operation, and is expected to be applied to industrial production. The method is convenient to operate and is low in cost, the tensile mechanical property and pore size of a common electrostatic spinning nano fiber scaffold can be effectively improved, and the method is expected to be applied to the fields of tissues and organs of tendon, ligament, mules, vessel and the like which have high requirements on the tensile mechanical property.

Description

technical field [0001] The invention belongs to the field of electrospinning tissue engineering scaffold and its preparation, in particular to a nano-yarn reinforced electrospinning fiber tissue engineering scaffold and a preparation method thereof. Background technique [0002] The failure, defect or dysfunction of organs and tissues seriously threatens the health and quality of life of patients, and also adds a heavy economic burden to the development of society. As an emerging tissue and organ regeneration technology, tissue engineering is expected to solve the shortcomings of traditional treatment methods, such as insufficient donors, immune rejection, disease transmission, and "injury treatment". Tissue engineering scaffolds, as the key to the success of tissue engineering regeneration and repair, need to provide a favorable microenvironment for the adhesion and proliferation of seed cells. Therefore, the construction of tissue engineering scaffolds is a research hotsp...

AI Technical Summary

Problems solved by technology

However, the electrospun nanofibers with small diameters are very easy to break due to external stress during the post-processing of the scaffold or the tissue regeneration process, and then destroy the overall structure of the nanofiber scaffold, thus creating obstacles for tissue regeneration.

Insufficient tensile mechanical strength limits the application of common electrospun tissue engineering scaffolds in the field of tendon, ligament, muscle and other organ regeneration

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