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Toltrazuril solution and preparation method thereof

A technology of toltrazuril and solution, which is applied in the field of veterinary toltrazuril solution and its preparation, can solve the problems of poor stability, low effective concentration and precipitation of toltrazuril, and achieve drug resistance and recovery Fast, rapid-growing effects

Inactive Publication Date: 2013-03-20
JIANGSU HFQ BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, most of the listed products of toltrazuril are powders and drinking water preparations, the effective concentration of which is low, and the stability of toltrazuril is poor, and precipitation and discoloration are prone to occur

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Weigh 2.0 g of toltrazuril, put it in a container, add 20 ml of propylene glycol, 400 ml of polyethylene glycol, and keep stirring for 30 minutes, then slowly add ethanolamine, and keep stirring, measure the pH value, make the added ethanolamine The amount can make the pH 9.5-10.0, and keep stirring to make the solution clear, and then add the remaining amount of absolute ethanol to make the solution 100ml.

Embodiment 2

[0019] Weigh 3.0g of toltrazuril, put it in a container, add propylene glycol 40ml, polyethylene glycol 40020ml and absolute ethanol 30ml, keep stirring for 30 minutes, then slowly add ethanolamine, and keep stirring, measure the pH value , so that the amount of ethanolamine added can make the pH 9.5-10.0, and constantly stir to make the solution clear, then add the remainder of absolute ethanol to make the solution 100ml.

Embodiment 3

[0021] Weigh 2.5g of toltrazuril, put it in a container, add polyethylene glycol 40035ml and propylene glycol 50ml, stir continuously for 30 minutes, then slowly add ethanolamine, and keep stirring, measure the pH value, make the added ethanolamine The amount can make the pH be 9.5-10.0, and keep stirring to make the solution clear, then add the remaining amount of propylene glycol to make the solution 100ml.

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PUM

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Abstract

The invention aims to disclose a toltrazuril solution and a preparation method thereof. Each 100mL of toltrazuril solution comprises the following components by weight: 2 to 5g of toltrazuril, 20 to 50mL of polyethylene glycol 400, 20 to 50g of propylene glycol, 0 to 40mL of anhydrous ethanol and a proper amount of ethanolamine. Compared with the prior art, the toltrazuril solution has the advantages that medicament resistance is avoided, the intracellular development stage of various coccidia and various medicament-resistant coccidium strains can be controlled by only using the toltrazuril solution for two days, and the safety is high, so that the toltrazuril solution can exert an optimal effect without affecting the growth and the utilization rate of a feed; and the toltrazuril solution can be mixed with multiple medicaments for use, remarkably reduces the death rate, realizes quick recovery and quick growth, saves resources, is easy to control and suitable for large-batch production, and fulfills the aims of the invention.

Description

technical field [0001] The invention relates to a solution and a preparation method thereof, in particular to a veterinary toltrazuril solution and a preparation method thereof. Background technique [0002] Chicken coccidiosis (Coccidiosis in Chicken) is a common and very serious parasitic disease in chickens. It is an acute epidemic parasitic disease caused by one or more coccidiosis. The economic damage it caused was staggering. The morbidity and mortality rate of 10-30 day old chicks or 35-60 day old young chickens can be as high as 80%. The growth of the sick chicks is hindered, and the weight gain is slow; the adult chickens generally do not get sick, but they are carriers, and the weight gain and egg production ability are reduced, which is an important source of spreading coccidiosis. [0003] The pathogen is the coccidia of the genus Eimeria in the Eimeriaceae in the protozoa. There are as many as 13 species of chicken coccidia recorded in countries all over the ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/53A61P33/02
Inventor 廖洪
Owner JIANGSU HFQ BIO TECH CO LTD
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