Optical biological detection method based on tri-doped lithium niobate crystal

A technology of biological detection and lithium niobate, which is applied in the direction of phase influence characteristic measurement, etc., can solve the problems of long writing grating time and affecting grating application, etc., and achieve fast real-time detection, high detection sensitivity, and low cost effects

Active Publication Date: 2013-03-20
TAIYUAN UNIV OF TECH
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Problems solved by technology

However, this method also has this problem. It takes too long to write the grating, which takes hundreds of minutes, which will seriously affect the application of the grating in high-sensitivity, real-time detection processing.

Method used

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  • Optical biological detection method based on tri-doped lithium niobate crystal
  • Optical biological detection method based on tri-doped lithium niobate crystal

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Embodiment Construction

[0031] The specific implementation manners of the present invention will be further described below.

[0032] Implementation of an optical biosensor detection method provided by the present invention, including the method of all-optical writing of a stable, non-volatile waveguide grating on a triple-doped lithium niobium crystal used in the method of the present invention, binding biometric recognition on the grating The molecule reacts specifically with the target molecule to change the optical properties, and then quantitatively detect the concentration of the target molecule. The specific detection method is carried out according to the following steps:

[0033] (1) Formation of the waveguide: Using the method of high-temperature titanium internal diffusion, the optical waveguide is formed on the surface of the z-cut y-propagated triple-doped Hf, Fe, Mn lithium niobate crystal, and the crystal surface is sequentially subjected to electron beam evaporation, flame hydrolysis, ...

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Abstract

The invention discloses an optical biological detection method based on tri-doped lithium niobate crystal. The optical biological method comprises the steps of: forming a waveguide grating substrate base on the tri-doped lithium niobate crystal, forming a waveguide on the substrate, forming a holographic bragg grating on the waveguide, forming a biological recognition molecule on the holographic bragg grating, forming a target molecule on the biological recognition molecule, forming waveguide grating reflection light wavelength change on the target molecule, and forming biomolecule concentration on the waveguide grating reflection light wavelength change. The method has the characteristic of full-gloss fast writing in a non-volatile holographic grating, and simultaneously realizes low cost, and high-precision, multi-flux, quick quantitative detection of the biological molecule, is applicable to quantitatively detecting micro concentration of harmful components, pesticide residue, narcotics and the like in the food, and has an extensive market prospect.

Description

technical field [0001] The invention relates to an optical biological detection method, in particular to an optical biological detection method based on a non-volatile holographic Bragg grating of triple-doped lithium niobate crystal. Background technique [0002] In 1967, Updike and Hicks assembled the glucose oxidase (GOD) immobilized membrane and oxygen electrode together to make the first biosensor based on the glucose enzyme electrode. After that, various biosensors for biological detection, such as Thermosensitive biosensors, field effect tube biosensors, piezoelectric biosensors, optical biosensors, acoustic channel biosensors, enzyme electrode biosensors, mediator biosensors, etc. are widely used in production and life. Among them, the optical-biosensor is a powerful detection and analysis tool, and it is one of the most widely studied and fastest-growing biosensors. [0003] According to different optical detection principles, it can be divided into surface plasm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/41
Inventor 李晓春崔彩娥张玲玲于化忠
Owner TAIYUAN UNIV OF TECH
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