The invention discloses a method for preparing a mesoporous MCM-22 silicon aluminum molecular sieve, which comprises the following steps: uniformly mixing the MCM-22 molecular sieve synthesized by a conventional hydrothermal method, an organic amine and 0.1M NaOH solution, filling in an enclosed reaction vessel, reacting under the self-generated pressure of 170 DEG for 1-24 hours, cooling the products, filtering, washing, drying, roasting at the temperature of 550 DEG C for 6 hours, exchanging by NH4Cl, roasting at the temperature of 550 DEG C for 6 hours again to obtain the mesoporous MCM-22 silicon aluminum molecular sieve. According to the invention, the intragranular mesoporous is introduced in the MCM-22 structure, thereby an intrastratal decacyclic sine pore and an inner part of an interlayer supercage are communicated, and the internal diffusion limitation can be improved. According to the invention, during the process of melt silicon by alkali treatment, an organic amine stable skeleton is employed, and the crystallization degree of the molecular sieve can be better maintained when the mesoporous can be prepared. The molecular sieve of the present invention is used for macro-molecule reaction, such as an alkylation reaction of benzene and isopropanol, compared with conventional MCM-22, the catalytic activity and the selectivity can be greatly enhanced, and the deactivation rate can be obviously slowed.