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Quality detection method for Huoxiang Zhengqi dripping pills

A quality inspection method and technology of Huoxiang Zhengqi Dropping Pills, applied in the field of medicine, can solve problems such as not being able to fully reflect the quality of products

Active Publication Date: 2013-03-27
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation is a compound preparation composed of 10 medicinal materials including patchouli oil, atractylodes rhizome, tangerine peel, and magnolia bark. However, in the existing detection methods, only the three medicinal materials of patchouli oil, angelica dahurica, and magnolia bark were qualitatively or Quantitative determination cannot fully reflect the quality status of the product

Method used

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  • Quality detection method for Huoxiang Zhengqi dripping pills
  • Quality detection method for Huoxiang Zhengqi dripping pills
  • Quality detection method for Huoxiang Zhengqi dripping pills

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Example 1 Atractylodes identification

[0086] Preparation of the test solution: Take 5.2g of this product, press the coating, add 20mL of water to dissolve it ultrasonically, add 20mL of cyclohexane to extract by shaking, separate the cyclohexane extract (the water layer is used as the identification of tangerine peel and licorice), Evaporate to dryness at low temperature, add ethyl acetate 1mL to dissolve the residue, and use it as the test solution.

[0087] Preparation of reference medicinal material solution and reference substance solution: Take 0.5 g of Atractylodes atractylodis as reference medicinal material, add 2 mL of cyclohexane, sonicate for 15 minutes, filter, and use the filtrate as the reference medicinal material solution. Take atractylodes reference substance, add methanol to make a solution containing 0.2mg per 1mL, as the reference substance solution.

[0088] Preparation of negative sample solution: According to the prescription ratio, take other ...

Embodiment 2

[0090] Example 2 Identification of Angelica dahurica

[0091] The preparation of need testing solution: need testing solution under " embodiment 1 " item.

[0092] Preparation of reference medicinal material solution and reference substance solution: Take 0.5 g of Angelica dahurica reference medicinal material, add 10 mL of ether, soak for 1 hour, shake frequently, filter, evaporate the filtrate to dryness, add 1 mL of ethyl acetate to the residue to dissolve, and use it as the reference medicinal material solution. Take imperatorin reference substance, isoimperatorin reference substance, add ethyl acetate to make a mixed solution containing 1mg per 1mL, as the reference substance solution.

[0093] Preparation of negative sample solution: According to the prescription ratio, get other medicinal materials except Angelica dahurica, prepare drop pills according to the process, and then make negative sample solution according to the preparation method of "Example 1" test solution...

Embodiment 3

[0094] Identification: test according to thin-layer chromatography (Chinese Pharmacopoeia 2010 edition one appendix VI B), draw the need testing solution under "Example 1" and the above-mentioned reference medicinal material, negative sample solution and reference substance solution respectively 3 ~ 5 μ L, Spot on the same silica gel G thin-layer plate, develop with petroleum ether (30-60°C)-diethyl ether (3:2) as developer, take it out, dry it, and inspect it under ultraviolet light (254nm). In the chromatogram of the test product, at the position corresponding to the chromatogram of the reference medicinal material and the reference product, there are fluorescent spots of the same color, and the negative sample has no interference. See diagram 2-1 . Embodiment 3 Magnolia officinalis, patchouli oil thin layer identification

[0095] The preparation of need testing solution: need testing solution under " embodiment 1 " item.

[0096] Preparation of the reference substance ...

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Abstract

The invention relates to the medicinal field, and concretely relates to a quality detection method for Huoxiang Zhengqi dripping pills. The quality detection method comprises an identification method and a content determination method, and the identification method comprises the steps of Atractylodes lancea identification, dahurian angelica root identification, cortex magnoliae officinalis and Pogostemon cablin oil thin-layer identification, Perilla frutescens leaf oil identification, dried orange peel identification, licorice identification and Pinellia Tuber idenfication and is carried out through using thin layer chromatography. The quality detection method also comprises the determination of the contents of effective components in the Huoxiang Zhengqi dripping pills, the effective components comprise hesperidins, magnolols and honokiols, and the content determination method is carried out through adopting high performance liquid chromatography.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a quality detection method for Huoxiangzhengqi dripping pills Background technique [0002] Huoxiang Zhengqi Dropping Pills is an exclusive variety produced by Tianjin Tasly Pharmaceutical Co., Ltd., as a representative dosage form of modern Chinese medicine developed by Tasly, it has the characteristics of high drug stability, not easy to be hydrolyzed and oxidized, quick onset of action, no peculiar smell, good taste, and easy to carry. . The preparation is a compound preparation composed of 10 medicinal materials including patchouli oil, atractylodes rhizome, tangerine peel, and magnolia bark. However, in the existing detection methods, only the three medicinal materials of patchouli oil, angelica dahurica, and magnolia bark were qualitatively or Quantitative determination cannot fully reflect the quality status of the product. The present invention improves the TLC identification me...

Claims

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Application Information

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IPC IPC(8): G01N30/90G01N30/88
Inventor 阚红玉孙玉侠曹凤兰陈明
Owner TIANJIN TASLY PHARMA CO LTD
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