Quality detection method for Huoxiang Zhengqi dripping pills

A quality inspection method and technology of Huoxiang Zhengqi Dropping Pills, applied in the field of medicine, can solve problems such as not being able to fully reflect the quality of products

Active Publication Date: 2013-03-27
TIANJIN TASLY PHARMA CO LTD
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  • Abstract
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Problems solved by technology

The preparation is a compound preparation composed of 10 medicinal materials including patchouli oil, atractylodes rhizome, tangerine peel, and magnolia bark. However, in the existing detection meth

Method used

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  • Quality detection method for Huoxiang Zhengqi dripping pills
  • Quality detection method for Huoxiang Zhengqi dripping pills
  • Quality detection method for Huoxiang Zhengqi dripping pills

Examples

Experimental program
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[0085] Example 1 Cangzhu identification

[0086] Preparation of test solution: take 5.2g of this product, crush the coating, add 20mL of water to dissolve ultrasonically, add 20mL of cyclohexane for extraction, and divide the cyclohexane extract (the water layer is used for identification of tangerine peel and licorice), Evaporate to dryness at low temperature, and add 1 mL of ethyl acetate to the residue to dissolve it as the test solution.

[0087] Preparation of reference medicinal material solution and reference material solution: take 0.5 g of Atractylodes lancea reference medicinal material, add 2 mL of cyclohexane, sonicate for 15 minutes, filter, and use the filtrate as the reference medicinal material solution. Take the atractylodes reference substance, add methanol to make a solution containing 0.2mg per 1mL, as the reference substance solution.

[0088] Negative sample solution preparation: According to the prescription, take other medicinal materials except atractylodes ...

Example Embodiment

[0090] Example 2 Identification of Angelica dahurica

[0091] Preparation of test solution: the same as the test solution under "Example 1".

[0092] Preparation of reference medicinal material solution and reference material solution: take 0.5g of Angelica dahurica reference medicinal material, add 10 mL of ether, soak for 1 hour, shake and filter, and evaporate the filtrate to dryness. Add 1 mL of ethyl acetate to the residue to dissolve it as a reference medicinal solution. Take the imperatorin reference substance and isoimperatorin reference substance, add ethyl acetate to make a mixed solution containing 1mg per 1mL, as the reference substance solution.

[0093] Preparation of negative sample solution: According to the prescription ratio, take other medicinal materials except Angelica dahurica, prepare dripping pills according to the process, and then prepare negative sample solution according to the preparation method of test solution in "Example 1".

[0094] Identification: Acc...

Example Embodiment

[0094] Identification: According to thin-layer chromatography (Chinese Pharmacopoeia 2010 edition one appendix VI B) test, absorb the test product solution under "Example 1" and the above-mentioned reference medicinal materials, negative sample solution and reference solution each 3 ~ 5μL, Spot them on the same silica gel G thin-layer plate, use petroleum ether (30-60°C)-diethyl ether (3:2) as the developing agent, unfold, take out, dry, and inspect under UV light (254nm). In the chromatogram of the test product, the fluorescent spots of the same color appear on the corresponding position of the chromatogram of the control medicinal material and the reference product, and the negative sample has no interference. see diagram 2-1 . Example 3 Identification of Magnolia officinalis and Patchouli Oil Thin Layer

[0095] Preparation of test solution: the same as the test solution under "Example 1".

[0096] Preparation of reference substance solution: take Baiqiuli alcohol reference s...

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Abstract

The invention relates to the medicinal field, and concretely relates to a quality detection method for Huoxiang Zhengqi dripping pills. The quality detection method comprises an identification method and a content determination method, and the identification method comprises the steps of Atractylodes lancea identification, dahurian angelica root identification, cortex magnoliae officinalis and Pogostemon cablin oil thin-layer identification, Perilla frutescens leaf oil identification, dried orange peel identification, licorice identification and Pinellia Tuber idenfication and is carried out through using thin layer chromatography. The quality detection method also comprises the determination of the contents of effective components in the Huoxiang Zhengqi dripping pills, the effective components comprise hesperidins, magnolols and honokiols, and the content determination method is carried out through adopting high performance liquid chromatography.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a quality detection method for Huoxiangzhengqi dripping pills Background technique [0002] Huoxiang Zhengqi Dropping Pills is an exclusive variety produced by Tianjin Tasly Pharmaceutical Co., Ltd., as a representative dosage form of modern Chinese medicine developed by Tasly, it has the characteristics of high drug stability, not easy to be hydrolyzed and oxidized, quick onset of action, no peculiar smell, good taste, and easy to carry. . The preparation is a compound preparation composed of 10 medicinal materials including patchouli oil, atractylodes rhizome, tangerine peel, and magnolia bark. However, in the existing detection methods, only the three medicinal materials of patchouli oil, angelica dahurica, and magnolia bark were qualitatively or Quantitative determination cannot fully reflect the quality status of the product. The present invention improves the TLC identification me...

Claims

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Application Information

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IPC IPC(8): G01N30/90G01N30/88
Inventor 阚红玉孙玉侠曹凤兰陈明
Owner TIANJIN TASLY PHARMA CO LTD
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