Application of active component baicalin of Qingkailing compound in preparation of medicines resisting multiple drug-resistance bacteria

Abstract

The invention relates to an active component baicalin of a Qingkailing compound, which has an inhibiting effect on acinetobacter calcoaceticus, acinetobacter baumannii, A.baumannii, stenotrophomonas maltophilia and escherichia coli containing NDM-1 drug resistance gene, so that the active component baicalin can be used for inhibiting these bacterial diseases and treating and/or preventing diseases caused by these bacteria.

Description

technical field [0001] The invention relates to a new medical application of baicalin, in particular to the application of baicalin in preparing anti-multi-drug-resistant bacteria drugs. Background technique [0002] Multiple resistant bacteria refer to pathogenic bacteria with multiple drug resistance, that is, one microorganism is resistant to three types (such as aminoglycosides, erythromycin, B-lactams) or more than three types of antibiotics at the same time. . The most common ones are NDM-1, MDR-TB, MDR-MRSA, and Acinetobacter baumannii and Pseudomonas aeruginosa that often appear in ICU. NDM-1 (New Delhi metallo-β-lactamase-1, New Delhi metallo-β-lactamase), also known as NDM-1 bacteria, is a carbapenem-resistant enzyme. The NDM-1 gene is often carried by a plasmid, but it is also integrated on the bacterial chromosome, which is easy to spread and spread among different strains. The molecular weight of the protein monomer encoded by NDM-1 is 28kDa, and its sequence ...

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Problems solved by technology

At present, multidrug-resistant bacterial infections are showing an increasing trend, but there are few

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