Application of Qingkailing active component radix isatidis extract in preparation of anti-multidrug-resistant bacterium medicine
A technology of Radix isatidis extract and multi-drug resistant bacteria, which can be applied in the directions of antibacterial drugs, resistance to vector-borne diseases, and medical preparations containing active ingredients, which can solve the problem of few options for antibacterial drugs
Active Publication Date: 2015-05-13
HEBEI SHINEWAY PHARMA
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Problems solved by technology
At present, multidrug-resistant bacterial infections are showing an increasing trend, but there are few antimicrobial drug options, so heavily drug-resistant bacterial infections have become a global problem
Method used
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Embodiment 1
[0023] Preparation method of isatidis extract
[0024] (1) Take an appropriate amount of dried Radix isatidis, crush it into a coarse powder, add 60 times the amount of water (or 20% ethanol), extract at 40°C to 70°C for 3 hours, and filter;
[0025] (2) Put the obtained filtrate on the macroporous adsorption resin, and then elute with 6-8 times the column volume of water and 12-15 times the column volume of 30% ethanol, collect the eluate, filter, and recover the ethanol under reduced pressure to No alcohol smell, get Radix isatidis extract, refrigerated.
[0026] Pharmacodynamic test
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The invention discloses a new medical application of a radix isatidis extract and provides a medicine capable of effectively antagonizing a multidrug-resistant bacterium. The radix isatidis preparation can be used for treating diseases caused by the multidrug-resistant bacterium containing an NDM-1 drug-resistant gene, such as intestinal infection, respiratory infection, wound and skin infections, urogenital infection, bacteremia, meningitis and the like, and is particularly applicable to treatment of various infectious diseases caused by calcium acetate acinetobacter, acinetobacter baumannii, stenotrophomonas maltophilia, or escherichia coli containing the NDM-1 drug-resistant gene.
Description
technical field [0001] The invention relates to a new medical application of Radix Radix Radix, in particular to the application of Radix Radix Radix extract in the preparation of anti-multi-drug-resistant bacteria drugs. Background technique [0002] Multiple resistant bacteria refer to pathogenic bacteria with multiple drug resistance, that is, one microorganism is resistant to three types (such as aminoglycosides, erythromycin, B-lactams) or more than three types of antibiotics at the same time. . The most common ones are NDM-1, MDR-TB, MDR-MRSA, and Acinetobacter baumannii and Pseudomonas aeruginosa that often appear in ICU. NDM-1 (New Delhi metallo-β-lactamase-1, New Delhi metallo-β-lactamase), also known as NDM-1 bacteria, is a carbapenem-resistant enzyme. The NDM-1 gene is often carried by a plasmid, but it is also integrated on the bacterial chromosome, which is easy to spread and spread among different strains. The molecular weight of the protein monomer encoded b...
Claims
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IPC IPC(8): A61K36/315A61K31/195A61P31/04
CPCY02A50/30
Inventor 刘军锋袁静张状年黄留玉李东王雪松姜海
Owner HEBEI SHINEWAY PHARMA
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