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Application of triterpenoid saponins extracted from taibai anemone

A technology of triterpene saponins and compounds, applied in the field of medicine, can solve the problem of anti-glioma activity that has never been seen before

Inactive Publication Date: 2011-12-28
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its chemical structure and cytotoxicity to K-562 human leukemia cells and BEL-7402 human liver cancer cells have been reported by us (Xiao-YangWang 1 , Xiao-Li Chen 1 *, Hai-Feng Tang 1 , Hui Gao 2 , Xiang-Rong Tian 3 , Ping-Hu Zhang 4 Cytotoxic Triterpenoid Saponins from the Rhizomes of Anemone taipaiensis.J Planta Med.2011, 23), but its anti-glioma activity has not been reported in the literature and patent applications

Method used

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  • Application of triterpenoid saponins extracted from taibai anemone
  • Application of triterpenoid saponins extracted from taibai anemone
  • Application of triterpenoid saponins extracted from taibai anemone

Examples

Experimental program
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Embodiment

[0021] Example: Extraction and Separation of Compounds

[0022]The raw material for preparing the compounds of the examples is the dry rhizome of Anemone taibai, the raw material weighs 5 kg, after being cut into pieces, 5 liters of ethanol with a concentration of 70% is added to carry out reflux extraction, and a total of 3 extractions are performed, the first two times for 2 hours, and the third time 1 hour. The extracts were combined, and the solvent was recovered under reduced pressure (recovery under reduced pressure is the suction filtration method commonly used in this industry, the same below), to obtain 650 grams of concentrated and dried ethanol extract. The extract was dispersed in 8 liters of water, degreased 2 times with sherwood oil, 8 liters each, and the aqueous phase after extraction was extracted 3 times with water-saturated n-butanol, 8 liters each time, to obtain sherwood oil (15 grams) and n-butyl ether respectively. Alcohol (110 g) two extraction sites. ...

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Abstract

The invention provides a triterpenoid-saponin compound, wherein the molecular formula is C52H84O21, and the chemical name is 3beta-O-{beta-D- xylopyranosyl-(1->3)-alpha-L-rhamnopyranosyl-(1->2)-[beta-D-glucopyranosyl(1->4)]-alpha-L-arabinopyranosyl}hederagenin. In-vitro anti-tumor tests indicate that the compound has a remarkable inhibiting action for C6 rat glioblastoma cells as well as four kinds of U87MG, U251MG, BT325 and SHG44 glioblastoma cells without influencing the growth of primarily-cultured human neuroglia cells. The compound is hopeful to be used for preparing a medicament for treating a glioma.

Description

technical field [0001] The invention relates to the technical field of medicine, and is a compound with anticancer activity isolated from anemone genus (Anemone taibai) peculiar to Shaanxi Province, specifically a triterpene saponin extracted and isolated from anemone taibai Compound and its application in the preparation of anti-glioma drugs. Background technique [0002] Human glioma is the most common type of intracranial tumor, with high morbidity and mortality, and the 5-year survival rate is 20% to 30%, accounting for half of all glioma patients with glioblastoma5 The annual survival rate is less than 5%. Chemotherapy drugs currently used to treat glioma mainly include nimustine (ACNU), carmustine, lomustine, procarbazine, methotrexate, and cyclophosphamide. , teniposide, etc., but the effective rate of these drugs on malignant glioma is low, generally less than 50%, and the survival time is not significantly prolonged, and it is easy to cause serious liver damage an...

Claims

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Application Information

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IPC IPC(8): C07J63/00A61K31/704A61P35/00A61P35/02
Inventor 杨志福王啸洋汤海峰曹军程光李华
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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