Moist antibacterial hydrogel dressing for curing diabetic foot ulcer

A technology of diabetic foot ulcers and hydrogels, applied in medical science, bandages, absorbent pads, etc., can solve the problems of psychological pressure, patient pain, frequent, once a day or every other day, etc., achieve low cost, convenient operation, The effect of accelerating wound healing

Active Publication Date: 2013-04-17
钟春燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The general wound treatment method uses traditional dressings, mainly gauze, cotton pads, wiping with iodophor, wet compressing with normal saline and using oily gauze or traditional Chinese medicine ointment, etc., the curative effect is not good
However, these

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0020] Example 1:

[0021] 1. Dissolve sodium alginate in double distilled water to obtain an aqueous solution of sodium alginate with a weight percentage of 1%. The silver nitrate is dissolved in the sodium alginate aqueous solution, wherein the mole percentage of silver ions is 0.01 mol / L. Sodium borohydride is used as the reducing agent, and the sodium alginate solution containing silver ions is gradually added dropwise to obtain a nano-silver sodium alginate solution.

[0022] 2. The separated and purified bacterial cellulose membrane produced by Acetobacter xylinum was immersed in a nano-silver sodium alginate solution for 20 minutes, and then freeze-dried to obtain a bacterial cellulose / nano-silver sodium alginate composite membrane. The composite film is immersed in a calcium chloride aqueous solution containing 1% calcium chloride by weight for 5 minutes to obtain a wet antibacterial hydrogel dressing that can treat diabetic foot ulcers. The dressing is a bacterial cellulo...

Example Embodiment

[0023] Example 2:

[0024] 1. Dissolve sodium alginate in double distilled water to obtain a sodium alginate aqueous solution with a sodium alginate weight percentage of 2%. The silver sulfate is dissolved in the sodium alginate aqueous solution, wherein the mole percentage of silver ions is 0.05 mol / L. Sodium citrate is used as a reducing agent and gradually added dropwise to an aqueous sodium alginate solution containing silver ions to obtain a nano-silver sodium alginate solution.

[0025] 2. The separated and purified bacterial cellulose membrane produced by Rhizobium is immersed in the nano-silver sodium alginate solution for 180 minutes, and then freeze-dried to obtain a bacterial cellulose / nano-silver sodium alginate composite membrane. The composite film is immersed in a calcium chloride aqueous solution containing 2% calcium chloride by weight for 20 minutes to obtain a wet antibacterial hydrogel dressing that can treat diabetic foot ulcers. The dressing is a bacterial ce...

Example Embodiment

[0026] Example 3:

[0027] 1. Dissolve sodium alginate in double distilled water to obtain a sodium alginate aqueous solution with a weight percentage of 3%. The silver phosphate is dissolved in the sodium alginate aqueous solution, wherein the mole percentage of silver ions is 0.1 mol / L. Vitamin C is used as a reducing agent, and is gradually added dropwise to a sodium alginate aqueous solution containing silver ions to obtain a nano-silver sodium alginate solution.

[0028] 2. The separated and purified bacterial cellulose membrane produced by Sarcina spp. is immersed in a nano-silver sodium alginate solution for 30 minutes, and then freeze-dried to obtain a bacterial cellulose / nano-silver sodium alginate composite membrane. The composite film is immersed in a calcium chloride aqueous solution containing 5% calcium chloride by weight, and the immersion time is 60 minutes. Finally, a wet antibacterial hydrogel dressing that can treat diabetic foot ulcers is obtained. The dressing...

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PUM

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Abstract

The invention discloses a moist antibacterial hydrogel dressing for curing diabetic foot ulcer, and relates to the technical field of medical instruments and preparation thereof. The dressing is prepared by the following steps: dissolving ionic compounds in sodium alga acid water solution, and obtaining nano-silver sodium alga acid solution through adding reducing agent; adopting the impregnation method, placing the nano-silver sodium alga acid solution in a bacterial cellulose membrane, so as to obtain bacterial cellulose/nano-silver sodium alga acid composite membrane through freeze drying; and immersing the composite membrane in calcium chloride water solution, and obtaining the moist antibacterial hydrogel dressing for curing diabetic foot ulcer. The dressing is a composite hydrogel membrane including bacterial cellulose hydrogel and nano-silver contained calcium alginatehydrogel. The preparation is convenient to operate and low in cost, and the moist antibacterial hydrogel dressing prepared for curing diabetic foot ulcer has the performances of sterilizing, preserving moisture, absorbing wound percolate, quickening wound healing and the like, and is applied to curing wound traumas of diabetic foot ulcer, venous ulcer, pressure sores and donor site wounds at the lower limbs.

Description

technical field [0001] The invention relates to the technical field of medical equipment and its preparation, in particular to a method for preparing a wet antibacterial hydrogel dressing for treating diabetic foot ulcers. Background technique [0002] Diabetic foot refers to infection, ulceration and / or deep tissue destruction of the foot (at or below the ankle) associated with distal neurological abnormalities and varying degrees of peripheral vascular disease in the lower extremities, mainly manifested as foot ulcers and gangrene. Diabetic foot is one of the main causes of disability in diabetic patients. 15% to 20% of diabetic patients develop foot ulcers or gangrene during the course of the disease, and the amputation rate of diabetic foot disease is 15 to 20 times that of non-diabetic patients. About 50% of non-traumatic amputations per year are diabetic patients. Once diabetic foot is diagnosed, on the basis of systemic treatment that removes the cause, strictly cont...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/18A61L15/44
Inventor 钟春燕其他发明人请求不公开姓名
Owner 钟春燕
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