Composition and preparation method and application thereof

A composition and mixture technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc.

Active Publication Date: 2013-04-24
CHANGZHOU ADAM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

None of the above drugs has ideal anti-altitude sickness effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 A composition is formed by mixing 10 parts of arginine, 1 part of citrulline, and 1 part of vitamin C by mass parts. The pH value of the solution was adjusted to about 7, and a 0.1343 g / ml solution was prepared.

Embodiment 2

[0028] Example 2 A composition is formed by mixing 20 parts of arginine, 10 parts of citrulline, and 1 part of vitamin C in parts by mass. The drug needs to be dissolved in a citric acid-Na2HPO4 buffer solution with a pH of Adjust the pH value of the acid solution to about 8, and make a 0.1343g / ml solution.

Embodiment 3

[0029] Example 3 A composition is formed by mixing 40 parts of arginine, 3 parts of citrulline, and 4 parts of vitamin C in parts by mass. The drug needs to be dissolved in a citric acid-Na2HPO4 buffer solution with a pH of 7.4, and then Use citric acid solution to adjust the pH value to about 7.4, and make a 0.1343g / ml solution.

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PUM

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Abstract

The invention relates to an altitude-sickness-resistance drug, in particular to a composition and a preparation method and application thereof. The composition is characterized by comprising arginine, citrulline and vitamin C. A novel composition is adopted by the composition, and the composition has obvious effect on improving anti-hypoxia capability of a mouse in a mouse anti-hypoxia experiment (a constant pressure anti-hypoxia experiment and an acute cerebral ischemia oxygen deficit experiment. The composition can effectively improve symptoms, such as headache, dizzy giddy, sleeplessness, hypomnesis, attention-deficit disorder, choking sensation in a chest, cardiopalmus, hard breathe and anorexia, of chronic high altitude reaction, is affirmative in curative effect and particularly suitable for high altitude myocardial anoxia patients suffering from choking sensation in the chest, cardiopalmus, hard breathe and the like in the high altitude reaction, and brings good news for people who enters into a high altitude area to work.

Description

technical field [0001] The invention relates to anti-altitude sickness medicine, in particular to a composition and its preparation method and application. Background technique [0002] Altitude sickness (AMS): some people who enter the plateau for the first time, at an altitude of 1000 meters, due to the decrease of the oxygen partial pressure in the atmospheric pressure, the body's tolerance to the hypoxic environment is reduced, and the adaptability is poor. Within 24 hours, headaches, Dizziness, vertigo, tinnitus, general fatigue, difficulty walking, difficulty falling asleep and a series of plateau maladaptive symptoms. In severe cases, symptoms of altitude sickness such as abdominal distension, loss of appetite, nausea, vomiting, palpitation, shortness of breath, chest tightness, purple complexion and lips, or facial edema may appear, which is called acute mountain sickness (AMS). Immigrants who have adapted to the plateau will also develop the disease when they retur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/375A61K31/198A61P39/00
Inventor 路易斯伊格纳罗张娟叶亚东滕凌朱文华全利潘鹂胡娟肖慧叶汝章杨紫俊张俊李永忠霍世元
Owner CHANGZHOU ADAM BIOTECH
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