Enteric-coated pharmaceutical excipient polymethacrylate emulsion and preparation method thereof
A technology of polymethacrylate and methacrylic acid, applied in the field of medicine, can solve the problems of desorption, poor stability of emulsion polymerization, gelation, etc.
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Embodiment 1
[0025] a. 68.5kg deionized water, 0.15kg potassium persulfate, 1.7kg emulsifier 2-allyl ether 3-hydroxypropane-1-sodium sulfonate, 1kg sodium lauryl sulfate and 0.6kg fatty alcohol polyoxyethylene ( 15) Add the ether into the pre-emulsification tank and stir to dissolve, add 21.3kg of methacrylic acid and 25.8kg of ethyl acrylate mixture at a temperature of 25°C and a stirring speed of 1200rad / min, and pre-emulsify for 3.5 hours to obtain a pre-emulsion for later use;
[0026] b. Add 68.5kg of deionized water and 0.12kg of potassium persulfate to the reactor, stir to raise the temperature to 82°C and keep it warm, and start to drop the pre-emulsion obtained in step a into the reactor, and the dropping time is 4h;
[0027] c. Heat at 82°C for 3 hours, cool naturally to 40°C, and filter through a 200-mesh filter to obtain an enteric-coated pharmaceutical excipient polymethacrylate emulsion with a solid content of 27%.
Embodiment 2
[0029] a. 90.8kg deionized water, 0.25kg ammonium persulfate, 2.85kg emulsifier 2-allyl ether 3-hydroxypropane-1-sodium sulfonate, 1.425kg sodium lauryl sulfate and 1.425kg fatty alcohol polyoxyethylene (7) Add the ether to the pre-emulsification tank and stir to dissolve. Add 46.5kg of methacrylic acid and 46.5kg of ethyl acrylate mixture at a temperature of 20°C and a stirring speed of 1200rad / min, and pre-emulsify for 4.5 hours to obtain a pre-emulsion for later use;
[0030] b. Add 136.2kg of deionized water and 0.08kg of ammonium persulfate into the reactor, stir and heat up to 85°C and keep it warm, then drop the pre-emulsion obtained in step a into the reactor, and the dropping time is 4.5h;
[0031] c. Heat at 85°C for 3 hours, cool naturally to 30°C, and filter through a 200-mesh filter to obtain an enteric-coated pharmaceutical excipient polymethacrylate emulsion with a solid content of 35%.
Embodiment 3
[0033] a. 234.37kg deionized water, 0.30kg potassium persulfate, 2.60kg emulsifier 2-allyl ether 3-hydroxypropane-1-sodium sulfonate, 2.80kg sodium lauryl sulfate and 1.2kg fatty alcohol polyoxyethylene (10) Ether is added here to the pre-emulsification tank and stirred to dissolve. At a temperature of 30°C and a stirring speed of 800rad / min, add 50kg of methacrylic acid and 55kg of ethyl acrylate mixture, and pre-emulsify for 0.5h to obtain a pre-emulsion for later use;
[0034] b. Then add 26.04kg of deionized water and 0.11kg of potassium persulfate to the reactor, raise the temperature to 50°C, and start to drop the pre-emulsion obtained in step a into the reactor, and the dropping time is 2h;
[0035] c. Reaction at 50°C for 2 hours, naturally cooled to 35°C, and filtered through a 200-mesh filter to obtain an enteric-coated pharmaceutical excipient polymethacrylate emulsion with a solid content of 30%.
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