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Application of aryl naphthalene type lignan in hepatitis C virus (HCV) therapy

A technology of viral hepatitis and lignan, applied in the field of natural medicinal chemistry, can solve the problems of side effects, unsatisfactory treatment effect, obvious and other problems

Inactive Publication Date: 2013-06-05
GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current standard treatment, including PEG-IFN / RBV combination, is only effective for more than half of the patients infected with hepatitis C virus (HCV), and has significant side effects, and the treatment effect of most patients infected with hepatitis C virus (HCV) not ideal

Method used

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  • Application of aryl naphthalene type lignan in hepatitis C virus (HCV) therapy
  • Application of aryl naphthalene type lignan in hepatitis C virus (HCV) therapy
  • Application of aryl naphthalene type lignan in hepatitis C virus (HCV) therapy

Examples

Experimental program
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Embodiment Construction

[0016] Specific implementation examples

[0017] Extraction and separation of compound 1

[0018] The red fish eye medicinal material (12.5kg) was naturally dried in the shade, crushed to 30 mesh, extracted twice with 75% ethanol under reflux, firstly added 12 times the amount of ethanol, and refluxed for 2 hours; twice, added 8 times the amount of ethanol, refluxed for 1 hour , filter the extract, reduce the alcohol solvent under reduced pressure until the alcohol content of the collected liquid is less than 10%, continue to evaporate and concentrate until there is no alcohol smell (relative density 1.20 / 80°C); add 2 times the amount of water, fully suspend, and use for suspension Petroleum ether is fully extracted until the extract is concentrated, then use vanillin-sulfuric ethanol reagent to check for no reaction, then use ethyl acetate to fully extract until the extract is concentrated, then use vanillin-sulfuric ethanol reagent to check for no reaction, then use n-butano...

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Abstract

The invention relates to application of an aryl naphthalene type lignan in hepatitis C virus (HCV) therapy and belongs to the technical field of medicine, and discloses an aryl naphthalene type lignan (red fish eye glycoside B) which has the activity of HCV resistance and is extracted and prepared from a Guangxi special Zhuang medicine, namely, red fish eye Phyllanthus reticulatus. The application of the aryl naphthalene type lignan in the HCV therapy is characterized in that obvious inhibitory effect (p < 0.01) is supplied to replicon ribonucleic acid (RNA) of HCV within a concentration range of 125 microgrammes per rnl to 15625 microgrammes per rnl, and a concentration range of non-cytotoxic drugs is from 0 to 3125 microgrammes per rnl (p < 0.01). According to the application of the aryl naphthalene type lignan in the HCV therapy, the market prospect of aryl naphthalene type lignan (red fish eye glycoside B) in HCV resistance new drug research and development is wide.

Description

technical field [0001] The present invention relates to the field of natural medicinal chemistry. Specifically, it relates to the application of an aryl naphthalene lignan in the treatment of hepatitis C virus (HCV). Background technique [0002] Phyllanthus retIIculatus, a specialty Zhuang medicine in Guangxi, is a plant of the genus Phyllanthus retIIculatus in the family Euphorbiaceae. In Zhuang medicine, red fish eye is often used to treat hepatitis, rheumatic joint pain and other diseases. [0003] Hepatitis C (hepatitis C) was initially defined as non-A non-B hepatitis after blood transfusion. In 1989, its pathogen was isolated and confirmed as hepatitis C virus (HCV, hepatitis C virus). There are 1.7 billion people in the world who are positive for HCV in serum. It infects about 3% of the global population, and there are 6 major genotypes of HCV, whose genomes differ by as much as 30%. In my country, HCV infection is mainly type II, and there are many mixed infection...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P31/14C07H17/04C07H1/08
Inventor 蓝鸣生谭昌恒马健雄陈路宋志军朱大元
Owner GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS
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