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Preparation method of medicine having liver protection and liver fibrosis effects

A liver fibrosis and action technology is applied in the field of preparation of medicines with liver protection and treatment of liver fibrosis, and achieves the effects of high efficiency, liver fibrosis protection and low temperature

Inactive Publication Date: 2013-06-05
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the problem in the prior art that there is no medicine with the functions of protecting the liver and treating liver fibrosis prepared from Qiaolinghua as a raw material, the present invention provides a preparation method of the medicine with the functions of protecting the liver and treating liver fibrosis

Method used

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  • Preparation method of medicine having liver protection and liver fibrosis effects
  • Preparation method of medicine having liver protection and liver fibrosis effects
  • Preparation method of medicine having liver protection and liver fibrosis effects

Examples

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preparation example Construction

[0029] A preparation method of a drug with functions of protecting the liver and treating liver fibrosis, comprising the following steps:

[0030] Step 1: Take dried Qiaolinghua as raw material, add 10-15 times the amount of water to soak for 24-36 hours, then ultrasonically extract 2-4 times at 60-80°C, 30-50 minutes each time, combine the extracts, and filter , the filtrate is concentrated under reduced pressure into an extract with a density of 1.05-1.12 for subsequent use;

[0031] Step 2: Take the extract prepared in Step 1, add food-grade ethanol to make the content of ethanol in the solution 50-70%, stir evenly and stand still for 36-72h, filter, discard the filter residue, recover the ethanol in the filtrate under reduced pressure, and concentrate to the extract, set aside;

[0032] Step 3: Dissolve the extract obtained in Step 2 with absolute ethanol, filter, mix and stir the filtrate with silica gel and diatomaceous earth, wherein the mass ratio of silica gel to dia...

Embodiment 1

[0059] A preparation method of a drug with functions of protecting the liver and treating liver fibrosis, comprising the following steps:

[0060] Step 1: Take 1 kg of dried Qiaolinghua with tender leaves, add 15 times the amount of water to soak for 36 hours, ultrasonically extract 4 times at 80°C, 50 minutes each time, combine the extracts, filter, and concentrate the filtrate to a density under reduced pressure The extract is 1.05-1.12, set aside;

[0061] Step 2: Take the extract prepared in Step 1, add food-grade 95% ethanol to make the ethanol content in the solution 70%, stir evenly and then stand still for 72 hours, filter, discard the filter residue, recover the ethanol in the filtrate under reduced pressure, and concentrate to immersion Ointment, spare;

[0062] Step 3: Dissolve the extract obtained in step 2 with 7 times the amount of absolute ethanol, filter, and mix the filtrate with a mixture of silica gel and diatomite whose mass multiple is 7 times the amount ...

Embodiment 2

[0067] A preparation method of a drug with functions of protecting the liver and treating liver fibrosis, comprising the following steps:

[0068] Step 1: Take 1 kg of dried Qiao Linghua containing twigs, add 15 times the amount of water to soak for 36 hours, ultrasonically extract 4 times at 80°C, 50 minutes each time, combine the extracts, filter, and concentrate the filtrate to a density under reduced pressure The extract is 1.05-1.12, set aside;

[0069] Step 2: Take the extract prepared in Step 1, add food-grade 95% ethanol to make the ethanol content in the solution 70%, stir evenly and then stand still for 72 hours, filter, discard the filter residue, recover the ethanol in the filtrate under reduced pressure, and concentrate to immersion Ointment, spare;

[0070] Step 3: Dissolve the extract obtained in step 2 with 5 times the amount of absolute ethanol, filter, and mix the filtrate with a mixture of silica gel and diatomite whose mass multiple is 4 times the amount o...

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Abstract

The invention relates to the technical field of medicine preparation, and concretely relates to a preparation method of a medicine having liver protection and liver fibrosis effects. The method which adopts a series of technologies comprising water extraction and alcohol precipitation, ultrasonic extraction, solid phase extraction, spray drying and the like to prepare Syringa pubescens granules or capsules. The medicine prepared in the invention has obvious liver protection and liver fibrosis effects, and the medicine effect substances have clear bases and controllable qualities; and the preparation method of the medicine provided by the invention has the advantages of simple process, easily available raw material, and suitableness for the large-scale industrialized production.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a preparation method of a medicine with functions of protecting the liver and treating liver fibrosis. Background technique [0002] Hepatic fibrosis (hepatic fibrosis, HF) is the repair response of liver tissue to repeated or chronic liver parenchymal inflammation, necrosis or chronic liver injury, etc. It is a series of complex effects of various types of cells, oxidative stress, cytokines and growth factors The main feature is hyperplasia and abnormal deposition of extracellular matrix (Extracellular Matrix, ECM) components. Liver fibrosis is an important pathological feature of chronic liver diseases (viral hepatitis, fatty liver, alcoholic liver, etc.), and a common pathological attribute of advanced liver diseases, which seriously threatens human health. If not treated in time, 25-40% of liver fibrosis will eventually It develops into liver cirrhosis and even...

Claims

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Application Information

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IPC IPC(8): A61K36/63A61K9/48A61P1/16A61K133/00A61K127/00A61K135/00
Inventor 刘普邓瑞雪尹卫平高嘉屿王怡冉牛亚琪柴元武时清亮
Owner HENAN UNIV OF SCI & TECH
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