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Erythromycin bacteria residue novel treatment method

An erythromycin residue and erythromycin technology are applied in the directions of microorganism-based methods, biochemical equipment and methods, microorganisms, etc., and can solve problems such as environmental pollution, so as to solve the problem of environmental pollution, protect the ecological environment, and reduce production. The effect of cost and energy consumption

Inactive Publication Date: 2013-06-19
SHANDONG FANGMING PHARMACEUTICAL CO LTD
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AI Technical Summary

Benefits of technology

In this patented method, which involves subjecting Erichthronium chloride (ErC) residues to primary or secondary ferments that break down their outer layer of cells without damaging them. These processes help release certain substances from these materials while also reducing harmful chemicals produced during decomposition. By adding specific types of enzymatic agents onto those material afterward, they degrade other components like sugars, proteins, acids, etc., resulting in improved products with reduced levels of unwanted side reactions such as nitrogen oxidants and volatile flavors. Additionally, when used on food crops, there're lesser risk than traditional methods due to its low content of potentially carcinogenous molecules found within EGCG. Overall, this process helps create safer and better sources of valuable bioactive ingredients called erythrolones.

Problems solved by technology

This patented technical problem addressed in this patent relates to developing new ways to use erythrocyte residue (ESR) without causing negative effects on humans or other animals that consume them.

Method used

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Examples

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Effect test

manufacture Embodiment 1

[0011] Manufacture Example 1: Process 100 kilograms of erythromycin slag to prepare the solid nutrients of erythromycin fermentation medium:

[0012] Strain preparation: monospore black;

[0013] Seed preparation: 20 grams of glucose, 10 grams of peptone, 5 grams of yeast extract, 12 grams of sodium chloride, 10 grams of ammonium sulfate, 1 gram of potassium dihydrogen phosphate, 0.5 grams of magnesium sulfate, 5 liters of water, the pH value is natural. 121 ℃ Sterilize for 20 minutes, after cooling down, insert the above-mentioned strains, and incubate at 30-33°C for 44 hours to obtain the seed solution.

[0014] Fermentation: 100Kg of erythromycin dried bacteria residue (moisture content about 15%), 6 Kg of dried brewer's grains, 12Kg of soybean meal, 6 Kg of bran, fully mix the fermentation substrate, add 10 Kg of black monosporus and 0.1 Kg of compound enzyme preparation is fermented, and the temperature is controlled below 32°C during the fermentation process, and the wa...

Embodiment 3

[0018] Dry erythromycin residue (moisture content about 70%) 70Kg, dried brewer's grains 5Kg, soybean meal 20Kg, bran 5Kg, water 120Kg, add water to the dry matter slowly and evenly, and then fully mix the fermentation substrate , at room temperature, insert 3Kg of Monosporus niger and 0.3 Kg of compound enzyme preparation for fermentation. During the fermentation process, the temperature is controlled below 55°C and the water content is 45-65%. After 48 hours of fermentation, it was dried and inactivated at 80°C for 15 minutes, then crushed and packaged to obtain 100Kg of bacterial protein. Its protein content ≥ 40%.

[0019] The thalline protein prepared in Example 1 of the present invention is used as the organic nitrogen component of the erythromycin fermentation medium to replace 30% of the soybean cake powder. Soybean cake powder 2.1%, ammonium sulfate 0.25%, light calcium carbonate 0.8%, bacterial protein 0.9% of the present invention (the control group uses the same a...

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PUM

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Abstract

The invention relates to a method for carrying out biological modification upon erythromycin bacteria residue and for reusing the modified product in fermentations of antibiotics such as erythromycin or macrolide. According to the erythromycin bacteria residue biological modification method, erythromycin bacteria residue and other industrial and agricultural by-products are adopted as substrates; a selective mixed flora is inoculated; compound enzyme preparation solid-state fermentation is carried out; and steps such as drying, crushing, sieving, packaging and the like are carried out. The treatment method provided by the invention has the characteristics of simple production process, easy operation, short treatment time, and high treatment efficiency. Compared with the original bacteria slag (with protein content of 17-25% and ash content of 21-27%), the protein content of the modified product (with protein content no lower than 28% and ash content no higher than 15%) is increased by 12-65%, and an ash content is reduced by 29-44%. The product can be reused as a fermentation medium for antibiotics such as erythromycin or macrolide, and fermentation titer can be improved. The invention provides a novel approach for solving problems of environment pollution and waste recycling in erythromycin production.

Description

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Claims

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Application Information

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Owner SHANDONG FANGMING PHARMACEUTICAL CO LTD
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