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Compound medicine having radiation resisting and protecting effects

A protection and anti-radiation technology, applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc.

Inactive Publication Date: 2013-06-26
唐俊琪 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In recent years, it has been found that Chinese herbal medicine has a good anti-radiation protective effect. However, the current treatment of Chinese herbal medicine is mostly limited to the research on the active ingredients of single Chinese medicine, while compound Chinese medicine preparations give full play to the characteristics of Chinese medicine treatment, aiming at the treatment of radiation damage based on syndrome differentiation. There are few research reports

Method used

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  • Compound medicine having radiation resisting and protecting effects
  • Compound medicine having radiation resisting and protecting effects
  • Compound medicine having radiation resisting and protecting effects

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] In order to maximize the yield, save energy and reduce waste as much as possible, in this example, the optimization research of the water extraction process was carried out for the drug.

[0031] Considering that American ginseng is the king drug of this medicine, it plays the main medicinal effect in the prescription. Saponin is an effective component of American ginseng to enhance the human body's righteousness and immunity. Therefore, the extraction and transfer rate of saponins was set as the evaluation index; at the same time, in the preparation process research, the amount of extract was an important influencing index, so the dry extract yield was set as another evaluation index. Through single factor experimental research, the levels of each factor in the orthogonal test are determined as follows:

[0032] Table 1: Table of experimental factor levels

[0033]

[0034] Based on the factors and levels screened out by the single-factor experiment, combined with...

Embodiment 2

[0046] Take 25g of American ginseng, 8g of Angelica sinensis, 12g of Nansha ginseng, 25g of Agrimony, and 10g of Chonglou, extract according to the water extraction method in Example 1, and concentrate the extract into 0.6g crude drug / ml extract.

Embodiment 3

[0049] Seventy-two Kunming male mice were randomly divided into normal group, model group, Zaofan pill group (drug positive control group), high-dose drug group, middle-dose drug group, and low-dose drug group, with 12 mice in each group. The normal group and the model group were intragastrically administered with 0.9% normal saline every day, the Zaofan pill group was intragastrically administered with Zaofan pills, and the administration group was administered with drug extracts in the high, medium and low dose groups respectively. Intervention for 10 days. One hour after intragastric administration on the 10th day, mice in the other groups except the normal control group received 5.5GY 60 Co ray whole body irradiation. After irradiation, the above groups continued to be administered by intragastric administration. Blood was collected from the orbits of each group on the 3rd, 9th, 17th and 23rd day after irradiation, and the blood routine was measured. On the 23rd day after...

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Abstract

The invention discloses a medicine used for nuclear radiation damage protection. Raw materials for preparing the medicine comprise 5-40 parts by weight of American ginseng, 2-25 parts by weight of Chinese angelica, 3-35 parts by weight of Adenophora stricta, 5-40 parts by weight of Agrimonia eupatoria and 3-30 parts by weight of Rhizoma Paridis. Experiments about the influences of <60>Co ray radiation caused blood-deficiency model mice, carried out by the applicant of the invention, confirm that the medicine used for nuclear radiation damage protection can effectively protect hemopoietic system and genital system damages caused by nuclear radiation and is a potential radiation resisting and protecting medicine.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a compound medicine with anti-radiation protection effect, which can effectively protect the hematopoietic system and reproductive system damage caused by nuclear radiation. Background technique [0002] With the wide application of nuclear energy and its radiation technology in various fields, the damage caused by nuclear radiation has become an important issue of increasing concern. Radiation therapy is generally a treatment method that irradiates tumors with rays of different energies to inhibit and kill cancer cells. It is one of the three major treatment methods for cancer. Normal cells are also negatively affected. Clinically, radiotherapy can easily cause bone marrow suppression, which in turn can lead to the destruction of hematopoietic function. Bone marrow suppression can be manifested as leukopenia in the early stage, and in severe ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61P37/04A61P7/00A61P15/00
Inventor 唐俊琪王晓娟唐志书
Owner 唐俊琪
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