Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Dextromethorphan hydrobromide and guaiacol glycerin ether oral liquid and preparation method thereof

A technology of guaiacol glycerol ether and dextromethorphan hydrobromide is applied in the directions of pharmaceutical formulations, ether/acetal active ingredients, medical preparations containing active ingredients, etc. Methorphan guaiacol glycerol ether solution drug stability and other issues, to achieve the effect of less impurities and high safety

Inactive Publication Date: 2013-07-10
UNIV OF SHANGHAI FOR SCI & TECH
View PDF4 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Yet above-mentioned application patent or invention patent all do not solve how to improve the drug stability of dextromethorphan guaiacol glyceryl ether solution of hydrobromide

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dextromethorphan hydrobromide and guaiacol glycerin ether oral liquid and preparation method thereof
  • Dextromethorphan hydrobromide and guaiacol glycerin ether oral liquid and preparation method thereof
  • Dextromethorphan hydrobromide and guaiacol glycerin ether oral liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] This example provides a study on the drug stability of dextromethorphan hydrobromide and guaiacol at different pH values ​​and the compatibility of raw materials and excipients used therein.

[0048] The following is the drug stability study of dextromethorphan hydrobromide and guaiacol at different pH values.

[0049] image 3 It is the result figure that the dextromethorphan hydrobromide in the embodiment carries out influence factor test under the condition that pH range is 3-7, Figure 4 It is the result figure of the influence factor test that the guaiacol glycerin in the embodiment is carried out under the condition of pH range 3-7, Figure 5 It is the result figure that the dextromethorphan hydrobromide in the embodiment carries out influence factor test under the condition of pH range 4.0-5.5, Figure 6 It is the result figure that the guaiacol glyceryl ether in the embodiment carries out the influence factor test under the condition that the pH range is 4.0-5...

Embodiment 2

[0068] In this example, the following formula was used to prepare 1000 mL of dextromethorphan guaiacol glyceryl ether oral liquid:

[0069]

[0070] 2N hydrochloric acid or sodium hydroxide solution to adjust the pH value of the solution to the range of 4.0-5.5, and the rest is purified water.

[0071] The preparation steps of dextromethorphan guaiacol glyceryl ether oral liquid of the present embodiment are as follows:

[0072] Dissolve 4.5g stevia, 1.5g dextromethorphan hydrobromide, 10g guaiacol glyceryl ether, 1.5g methylparaben, 1.5g ethylparaben, 2g mint essence, 6mg sunset yellow in 800ml purified water and stir After dissolving, then add 1 g of activated carbon and stir for 10 min, then remove the activated carbon by filtration to obtain solution 1;

[0073] Using 2N hydrochloric acid solution or sodium hydroxide solution to adjust the pH value of solution 1 to the range of 4.0-5.5 to obtain solution 2;

[0074] Add purified water into solution 2 until the volume ...

Embodiment 3

[0079] In this example, the following formula was used to prepare 1000 mL of dextromethorphan guaiacol glyceryl ether oral liquid:

[0080]

[0081] 2N hydrochloric acid solution or sodium hydroxide solution to adjust the pH of the solution to the range of 4.0-5.5, and the rest is purified water.

[0082] The preparation steps of dextromethorphan guaiacol glyceryl ether oral liquid of the present embodiment are as follows:

[0083] Dissolve 3.0g sucralose, 1.5g dextromethorphan hydrobromide, 10g guaiacol glyceryl ether, 1.5g methylparaben, 1.5g ethylparaben, 2g orange essence, 6mg tartrazine in 800ml purified water After stirring and dissolving, then add 1 g of activated carbon and stir for 10 minutes, then remove the activated carbon by filtration to obtain solution 1;

[0084] Using 2N hydrochloric acid solution or sodium hydroxide solution to adjust the pH value of solution 1 to the range of 4.0-5.5 to obtain solution 2;

[0085] Add purified water into solution 2 unti...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a dextromethorphan hydrobromide and guaiacol glycerin ether oral liquid. The oral liquid contains dextromethorphan hydrobromide, guaiacol glycerin ether, acidifying and alkalizing agents and purified water, wherein the acidifying and alkalizing agents are used for regulating the pH value of the dextromethorphan hydrobromide and guaiacol glycerin ether oral liquid to be 4.0-5.5.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a dextromethorphan guaiacol glyceryl ether oral liquid and a preparation method thereof. Background technique [0002] Cold is a kind of common respiratory disease that can take place in four seasons. It is caused by various viruses or germs. If it is not treated in time, it can cause many complications, such as pneumonia, myocarditis, etc., and bring serious harm to people's health. Bronchitis is a common disease of the elderly in winter. According to statistics, the incidence rate of middle-aged and elderly people over 50 years old in my country is 15-30%. The clinical symptoms of respiratory tract infection and bronchitis have cough, expectoration, have a strong impact on people's normal work and life. [0003] Dextromethorphan hydrobromide is a central antitussive drug, which can inhibit the medulla cough center and produce antitussive effect. Its anti...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/485A61K9/08A61P11/10A61P11/14A61K31/09
Inventor 刘哲鹏屠璐赵转霞贺文军
Owner UNIV OF SHANGHAI FOR SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com