Stirring reactor adopting film tube aeration

A stirred reactor and membrane tube technology, which is applied to special-purpose bioreactor/fermenter, bioreactor/fermenter combination, biochemical instrument, etc., can solve the problem of unfavorable aerobic microbial fermentation and low volume mass transfer coefficient , limit the growth of bacteria and other problems, and achieve the effect of good control, large quantity, and convenient disassembly and maintenance

Inactive Publication Date: 2013-07-31
NANJING TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a stirred reactor using membrane tube aeration to solve the problem of low volume mass transfer coefficient obtained by adopting nozzle type and orifice type gas distribution in the existing stirred reactor, which is not conducive to aerobic microorganisms Problems with fermentation, limited bacterial growth, and metabolism

Method used

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  • Stirring reactor adopting film tube aeration
  • Stirring reactor adopting film tube aeration

Examples

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Effect test

Embodiment 1

[0018] figure 1 It is a structural schematic diagram of the present invention, figure 2 yes figure 1 The top view of the A-A direction in the middle, combined with figure 1 , figure 2 As shown, the stirred reactor using membrane tube aeration includes a stirred reactor 1, and a plate-fin heat exchanger 2 with a plurality of fan-shaped plate-fin heat exchangers is arranged in the stirred reactor 1, and the fan-shaped Plate-fin heat exchangers are used to exchange heat. The upper end of the plate-fin heat exchanger 2 has a steam inlet and cooling water outlet flange 3, and the lower end has a steam condensate outlet and a cooling water inlet flange 7, wherein the steam inlet and cooling water outlet flange 3 pass through the ring pipe 4 The fan-shaped plate-fin heat exchangers are connected as a whole, and the steam condensate outlet and the cooling water inlet flange 7 connect the fan-shaped plate-fin heat exchangers as a whole through the ring pipe 26 to facilitate the f...

Embodiment 2

[0022] This example is used to illustrate the use of 10 m 3 The method for fermenting and producing L-lysine in a reactor using a membrane tube aeration method.

[0023] First, the culture medium is sterilized, and the stirring motor is turned on at a speed of 100 r / min, so that the fermentation broth is evenly heated. When the temperature rises above 95 degrees, the stirring can be stopped. Carry out the sterilization of the air filter and the air pipeline again, and slightly open the filter and the drain valve to ensure the sterilization of the air pipeline. Finally, the outlet, sampling valve, steam valve and outlet valve are slightly opened to ensure that the pipeline is sterilized.

[0024] Fermentation culture and results: Escherichia coli producing L-lysine (purchased from CGMCC, strain preservation number CGMCC1.0281) was inserted into a 5 m 3 10 m of fermentation medium 3 In a stirred reactor with membrane tube aeration (1L fermentation medium contains: glucos...

Embodiment 3

[0027] This example is used to illustrate the use of 50 m 3 Method for fermenting and producing citric acid in reactor using membrane tube aeration

[0028] First, the culture medium is sterilized, and the stirring motor is turned on at a speed of 100 r / min, so that the fermentation broth is evenly heated. When the temperature rises above 95 degrees, the stirring can be stopped. Carry out the sterilization of the air filter and the air pipeline again, and slightly open the filter and the drain valve to ensure the sterilization of the air pipeline. Finally, the outlet, sampling valve, steam valve and outlet valve are slightly opened to ensure that the pipeline is sterilized.

[0029] Fermentation culture and results: According to the inoculation amount of 10%, citrate-producing Aspergillus niger (purchased from CGMCC, the preservation number of Aspergillus niger is CGMCC5343) was inserted into a 35m 3 50m of fermentation medium 3 In an aerated reactor using membrane tubes (...

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Abstract

The invention relates to a stirring reactor adopting film tube aeration. The stirring reactor adopting film tube aeration comprises a stirring reactor, the bottom of the stirring reactor is provided with a gas distributor, and the gas distributor is connected with a film tube having nanometer level apertures. The stirring reactor adopting film tube aeration, which allows the film tube to be applied to the stirring reactor and utilizes the nanometer level apertures of the film tube, makes bubbles escaping from the film tube have small diameters and a large quantity, overcomes the large bubbles of a nozzle distributor and a perforated plate distributor, substantially increases the mass transfer performance, and is in favor of the control of dissolved oxygen in a fermentation liquid.

Description

technical field [0001] The invention belongs to the field of stirred reactors, and relates to a stirred reactor adopting membrane tube aeration. Background technique [0002] Bioreactor is an essential equipment for microbial fermentation, animal and plant cell culture, and production of various biological products and fermented products. Its function is to enhance mass transfer and heat transfer, and provide a stable growth environment for microorganisms or animal and plant cells. At present, a variety of bioreactors have come out. According to their mixing methods, they can be divided into mechanically stirred reactors, airlift reactors, and air bubbling reactors. They can be used for the production of certain specific substances. The development of the industry plays an important role in promoting. [0003] The solubility of oxygen in water is low. Under normal temperature and pressure, the solubility of oxygen in pure water is 0.2mmol / L, and the solubility in fermen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/04C12M1/02
Inventor 李干禄韦策李晖吴兵陈可泉欧阳平凯
Owner NANJING TECH UNIV
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