Chinese medicine fumigation-washing decoction for treating capecitabine extremities syndrome

Abstract

The invention relates to the field of Chinese medicine formulas, and in particular relates to a Chinese medicine fumigation-washing decoction for treating capecitabine extremities syndrome. The Chinese medicine fumigation-washing decoction is characterized by comprising bulk drugs in parts by weight: 20-30 parts of astragalus membranaceus, 15-20 parts of safflower, 15-20 parts of geranium wilfordii, 12-18 parts of Szechuan lovage rhizome, 12-18 parts of cassia twig, 12-18 parts of herba epimedii, 12-18 parts of common clubmoss herb, 12-18 parts of clematis root, 12-18 parts of incised notopterygium rhizome and 12-18 parts of pubescent angelica root. The ten bulk drugs are mixed and soaked with water, and are decocted and boiled and deslagged to obtain a filter liquid. The Chinese medicine fumigation-washing decoction is low in cost, high in curative effect and has the functions of tonifying qi, promoting blood circulation to remove meridian obstruction, and warming channel and expelling cold to stop pain, and the toxic and side effects are avoided, so that an effect of treating the Capecitabine extremities syndrome is realized well.

Description

technical field [0001] The invention relates to a Chinese patent medicine preparation, in particular to a traditional Chinese medicine fumigation and washing decoction for treating capecitabine-induced hand-foot syndrome. Background technique [0002] As we all know, hand-foot syndrome (hand-foot syndrome, HFS) was first reported in 1984 by Jacob Lokich and Chery Moore of Harvard Medical School, England's Daikenes Hospital. This specific skin syndrome occurs in 25% of patients receiving doxorubicin chemotherapy. Also known as palmar plantar erythrodyses-thesia (PPES), the main clinical manifestations are heat, pain, and erythematous swelling of the fingers / toes, and in severe cases, desquamation, ulceration, and severe pain develop, affecting daily life . A variety of chemotherapy drugs can cause hand-foot syndrome, which can also be seen in cytarabine, cyclophosphamide, docetaxel, vinorelbine, etc. In recent years, hand-foot syndrome caused by capecitabine has been partic...

AI Technical Summary

Problems solved by technology

However, it is very obvious that HFS brings pain and discomfort to patients, and there is currently a lack of high-quality randomized controlled trials to confirm that reduction or withdrawal of drugs will not affect the effect of chemotherapy

Therefore, how to prevent and treat HFS is a problem that needs to be considered when using capecitabine. At present, the commonly used clinical methods include local application of nicotine patch, systemic and local application of steroids, oral administration of vitamin E, vitamin B6 and cyclooxygenase -2 inhibitors, etc., have shown certain curative effects, but while the benefits are observed, the increased risk of death due to cardiovascular events (myocardial infarction, shock, heart failure) has also caused many phase I / II studies to be rejected. Therefore, the benefit / risk analysis of clinical treatment still needs further research

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