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Externally-applied Chinese medicinal composition for treating metastatic cancer-induced bone pain

A transferable, compositional technology, applied in the directions of drug combinations, non-central analgesics, medical preparations containing active ingredients, etc., can solve the problems of drug resistance and potential addiction risks that are difficult to eliminate, expensive, etc. Good application prospect, simple preparation, good curative effect

Active Publication Date: 2013-09-11
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment plan of long-term oral administration of three-step analgesics combined with regular application of bisphosphonates is generally used clinically, and satisfactory results have been achieved, but there are high prices, dry mouth, constipation, nausea, and vomiting caused by opioid analgesics. Problems such as fatigue, and the risk of drug resistance and potential addiction caused by continuous application are difficult to eliminate

Method used

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preparation example Construction

[0015] The specific embodiment of the preparation of composition powder and method of use is as follows:

[0016] According to the ratio of 50±5 grams of rhubarb and 300±30 grams of Glauber’s salt, dry the two medicines and grind them into powders, pass through a 100-mesh sieve, mix them evenly, and put them into double-layer cloth bags (about 30cm long and 20cm wide) , spread evenly, and fix the most obvious bone pain. The external application bag needs to be replaced every 12 hours.

[0017] According to the ratio of 100±10 grams of rhubarb and 200±20 grams of Glauber’s salt, dry the two medicines and grind them into powders, pass through a 100-mesh sieve, mix them evenly, and put them into double-layer cloth bags (about 30cm long and 20cm wide) , spread evenly, and fix the most obvious bone pain. The external application bag needs to be replaced every 12 hours.

[0018] According to the ratio of 80 ± 8 grams of rhubarb and 400 ± 40 grams of Glauber's salt, dry the two me...

example 1

[0025] Cheng, female, born in March 1962, is from Shanghai. Inpatient medical record number: 552323. He went to see a doctor because of "5 years after operation for uterine leiomyosarcoma, 2 years for liver metastasis, and 2 weeks for lumbar spine metastasis". The patient's lumbar spine MRI in May 2011 showed multiple metastases with some pathological fractures. On June 23, 2011, he suddenly experienced severe waist pain with a score of 8 points. Physical examination: bilateral lower extremity muscle strength grade 0, muscle tension grade 0, bilateral hypoesthesia below the knee joints, pain sensitivity, bilateral knee reflexes and Achilles tendon reflexes disappeared. Routine symptomatic support treatment, at the same time externally applied Chinese medicine compound preparation of the present invention on the waist, raw rhubarb 100 grams, Glauber's salt 400 1 time per day, continued 2 hours, continuous 14 days. Pain symptoms were significantly relieved, and the score was 4...

example 2

[0027] Yan, female, born in May 1957, from Shanghai, hospitalized case number: 654349. He went to see a doctor because of "discovered double breast cancer for 2 years and 5 months, extensive metastasis of thoracolumbar spine with pain for 1 year". In February 2012, MRI of the spine showed that the spine (T3-T12 in the thoracic, L1-L4 in the lumbar) had extensive metastatic tumors in multiple vertebral bodies and accessories, and pathological fractures in some vertebral bodies. Physical examination: the pain score was 6 points, the muscle strength of both lower limbs was grade 3, and the muscle tension was grade 4. The deep and shallow sensations of both lower limbs were normal, and bilateral knee reflexes and Achilles tendon reflexes existed. External application of the Chinese medicine compound preparation of the present invention on the chest and waist, 100 grams of raw rhubarb, 400 grams of Glauber's salt, once a day, 2 hours each time, continuous external application for 6...

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Abstract

The invention relates to an externally-applied Chinese medicinal composition for treating metastatic cancer-induced bone pain, and the Chinese medicinal composition is characterized by being prepared by the following Chinese medicine raw materials in parts by weight: 50-100 parts of rheum officinale and 200-400 parts of mirabilite. The externally-applied Chinese medicinal composition is aimed at metastatic cancer-induced bone pain, by taking pain-relieving, heat-clearing and stagnation-eliminating as a principle of treatment, and by verification through the clinical application of many years and pharmacological studies, the externally-applied Chinese medicinal composition can help to obviously improve the clinical symptom of the metastatic cancer-induced bone pain, and has advantages of definite therapeutic effect, no toxic and side effects, low cost and convenient application.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to an external Chinese medicine composition for treating metastatic cancerous bone pain; in addition, the invention also relates to the medical application of the Chinese medicine composition. Background technique [0002] The incidence of advanced cancer pain is as high as 75%-90%, of which bone pain caused by tumor bone metastasis, that is, metastatic cancer-induced bone pain (CIBP) accounts for about 40%. Bone metastasis is the most common metastasis of advanced malignant tumors, which can occur in any tumor, especially breast cancer, lung cancer and prostate cancer. However, if patients with bone metastases have not developed internal organ metastasis, their survival time may be relatively long. Patients will continue to suffer from severe bone pain and limited mobility for a long time, and they will also face pathological fractures, nerve root compression, and spinal cord injury at any ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/708A61K9/14A61P35/04A61P19/08A61P29/00A61K33/04
Inventor 俞超芹翟东霞韩洁白玲玲张丹英俞瑾王针织孙帅周丽虹
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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